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AB18633

Anti-HIV1 gp41 antibody [1D4]

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Mouse Monoclonal ENV antibody. Suitable for ELISA, WB and reacts with Human immunodeficiency virus samples.

View Alternative Names

Glycoprotein 41, Human Immunodeficiency Virus 1, TM, Transmembrane protein, gp41

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1D4

Isotype

IgG1

Carrier free

No

Reacts with

Human immunodeficiency virus

Applications

ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human immunodeficiency virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/1000", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Ammonium sulphate precipitate
Storage buffer
pH: 7.2 - 7.6 Preservative: 0.01% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HIV1 gp41 protein also known as the gp41 HIV protein is a glycoprotein that plays a mechanical role in the virus's capacity to fuse with host cells. This protein is 41 kDa in mass and is part of the viral envelope expressed on the surface of the HIV virus. Gp41 works closely with the gp120 protein to facilitate the fusion process a critical step in viral entry into lymphocytes. The 1d4 is sometimes used to refer to certain related domains or epitopes within the gp41 structure.
Biological function summary

During the infection process gp41 acts by mediating membrane fusion between the HIV viral envelope and the host cell membrane. It forms part of the Env complex consisting of gp120 and gp41 proteins which together create the functional envelope glycoprotein spike on the virus. This spike binds to receptors on the host cell such as the CD4 molecule which initiates changes that reveal the gp41 protein allowing it to insert into the host cell membrane and pull the viral and cellular membranes together.

Pathways

Involving HIV1 gp41 and its associated proteins the gp41 protein is a critical player in the viral entry pathway. After gp120 binds to the CD4 receptor and coreceptors such as CCR5 or CXCR4 on the host cell this conformational change exposes gp41 to carry out the fusion of viral and host membranes. The Env complex through gp41 and gp120 proteins coordinates this entry process integrating the viral genetic material with the host genome which is important for HIV propagation.

Involving the HIV1 gp41 protein it is directly related to the progression of HIV/AIDS. Gp41's function in viral entry makes it a target for antiviral drugs and vaccine development as inhibiting gp41 could block the virus from invading host cells. The interplay with gp120 and the interaction with host proteins like CD4 highlight the potential for gp41 as a therapeutic target in efforts to prevent or treat HIV infection.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HIV1 gp41
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Product promise

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