Anti-HIV1 p55 + p17 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Gag polyprotein functions as a scaffold for the formation of viral particles. It associates with the inner cell membrane of the infected cell to form virus-like particles. HIV1 p55 is part of a larger complex that involves interactions with the viral RNA and host proteins facilitating the budding of new viral particles from the infected cell. The p17 component also called the HIV-1 Matrix protein is integral in directing Gag to the plasma membrane where assembly occurs.

Pathways

The HIV1 p55 plays central roles in the viral replication cycle. It participates in pathways that facilitate viral assembly and release. During these processes Gag interacts with proteins such as TSG101 and ALIX which are involved in the endosomal sorting complex required for transport (ESCRT) pathway. This interaction is important for the budding process allowing the nascent viral particles to exit the host cell efficiently.