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AB70599

Anti-HIVEP2 antibody [2418C2a]

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(1 Publication)

Mouse Monoclonal HIVEP2 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HIVEP2.

View Alternative Names

Transcription factor HIVEP2, Human immunodeficiency virus type I enhancer-binding protein 2, MHC-binding protein 2, HIV-EP2, MBP-2, HIVEP2

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2418C2a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HIVEP2.

P31629

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
ab70599 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIVEP2 also known as Zinc Finger Transcription Factor influences transcription processes by binding to specific DNA sequences. This protein weighs approximately 568 kDa. It primarily appears in the brain and heart with notable expression in these tissues. HIVEP2 acts as a vital component in regulating transcription factors and it plays a significant role in the transcriptional regulation of immune-related genes.
Biological function summary

HIVEP2 regulates gene expression essential for normal cellular functions. Researchers identified it as a part of transcription complexes that control the expression of several immune and developmental genes. Through its zinc finger domains HIVEP2 binds to NF-kB DNA binding sites and influences immune response and inflammatory pathways. These interactions make it a critical component in modulating genes essential for cellular homeostasis and response to stimuli.

Pathways

The HIVEP2 protein participates in NF-kB signaling and Wnt signaling pathways. In these pathways HIVEP2 partners with other proteins like RELA and TCF7L2 to mediate cellular processes such as inflammatory responses and development. These pathways are important for maintaining cellular responses to extrinsic and intrinsic signals establishing HIVEP2 as a critical modulator in maintaining cellular integrity.

HIVEP2 relates to neurodevelopmental disorders and certain cancers. Alterations in HIVEP2 expression or function can link to intellectual disability and developmental delay due to its role in brain development. Furthermore its involvement in NF-kB signaling connects it to inflammatory pathways implicated in tumorigenesis. HIVEP2 interacts with proteins like RELA in these pathways underlying its importance in disease mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
See full target information HIVEP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 8:46219-46233 PubMed28515355

2017

Translational reprogramming of colorectal cancer cells induced by 5-fluorouracil through a miRNA-dependent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Zeina Bash-Imam,Gabriel Thérizols,Anne Vincent,Florian Lafôrets,Micaela Polay Espinoza,Nathalie Pion,Françoise Macari,Julie Pannequin,Alexandre David,Jean-Christophe Saurin,Hichem C Mertani,Julien Textoris,Didier Auboeuf,Frédéric Catez,Nicole Dalla Venezia,Martin Dutertre,Virginie Marcel,Jean-Jacques Diaz
View all publications
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Product promise

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