Anti-hlgB antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The hlgB protein also known as gamma-hemolysin component B or leucotoxin B is part of the gamma-hemolysin complex. This protein is recognized for its role in membrane disruption consisting of two components that work together to form pores in target cell membranes. The hlgB protein has a molecular mass of approximately 34 kDa and is expressed primarily by Staphylococcus aureus. It contributes to the bacterium’s virulence by targeting and lysing host cells.

Biological function summary

Gamma-hemolysin component B and its partner proteins form a two-component system. HlgB pairs with another component hlgA or hlgC to interact with the phospholipids in host cell membranes leading to the formation of transmembrane pores. This activity disrupts cellular homeostasis resulting in cell lysis. As a part of the hemolysin family hlgB contributes to the immune evasion strategies of bacteria by damaging host immune cells including leukocytes.

Pathways

HlgB is involved in pathways that enable bacterial immune evasion and pathogenesis. An important pathway it participates in is the induction of pore formation in leukocytes creating immune suppression. Related proteins in this pathway include other hemolysins like alpha-hemolysin that also contribute to pore formation and cytotoxic activities.

Associated diseases and disorders

HlgB is significant in its relation to staphylococcal infections including skin infections and pneumonia. It represents a virulence factor that worsens disease severity by facilitating bacterial penetration and persistence in host tissues. The interaction with other proteins like PVL (panton-valentine leukocidin) further enhances its pathogenic potential contributing to severe outcomes in staphylococcal disease manifestations.