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AB155787

Anti-HMGCS1 antibody

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(23 Publications)

Rabbit Polyclonal HMGCS1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 23 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HMGCS1 aa 150-500.

View Alternative Names

HMGCS, HMGCS1, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-HMGCS1 antibody (AB155787)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HMGCS1 antibody (AB155787)

Immunofluorescence analysis of HeLa cells fixed in 4% paraformaldehyde at RT for 15 min labelling HMGCS1 protein at cytoplasm using ab155787 at a 1/500 dilution (Green). Hoechst 33342 was used for nuclear staining (Blue). Scale bar = 10 µm

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human HMGCS1 aa 150-500. The exact immunogen used to generate this antibody is proprietary information.

Q01581

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HMGCS1 protein also known as 3-hydroxy-3-methylglutaryl-CoA synthase 1 functions as an enzyme with an approximate molecular weight of 57 kDa. This enzyme catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA to form HMG-CoA a critical step in the mevalonate pathway. HMGCS1 is expressed in various tissues with high levels detected in the liver. It plays a role in cholesterol biosynthesis reflecting its importance in metabolic processes.
Biological function summary

This enzyme contributes to the synthesis of cholesterol and other isoprenoids. HMGCS1 is not typically part of a multi-protein complex but operates downstream of acetyl-CoA in the mevalonate pathway. Its activity helps maintain cellular homeostasis by regulating the pool of HMG-CoA an important precursor in cholesterol and ketone bodies synthesis. The modulation of HMGCS1 activity impacts cellular proliferation and growth given the pathway's connection to sterol and non-sterol isoprenoid production.

Pathways

The enzyme participates chiefly in the mevalonate and cholesterol biosynthesis pathways. It functions alongside HMG-CoA reductase (HMGCR) which converts HMG-CoA to mevalonate further linking to cholesterol synthesis and regulatory pathways. The interrelation of HMGCS1 with other enzymes like HMGCR highlights its significance in lipid metabolism and cellular energy balance influencing pathways essential for cell membrane synthesis and signaling molecules production.

Alterations in HMGCS1 expression or function can associate with dyslipidemia and cardiovascular disease. Elevated levels of cholesterol due to disruptions in the mevalonate pathway implicate HMGCS1 in these disorders. Moreover mutations or heterogeneity in HMGCS1 activity may connect with metabolic syndrome where the pathways involving cholesterol biosynthesis play a role. Additionally understanding interactions with proteins such as HMGCR could provide insights into therapeutic targets for hypercholesterolemia and related cardiovascular conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
See full target information HMGCS1
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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Proteomes 13: PubMed40559991

2025

Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling.

Applications

Unspecified application

Species

Unspecified reactive species

Anu Jain,Rafaela Muniz de Queiroz,Jayanta K Chakrabarty,Karl A T Makepeace,Carol Prives,Lewis M Brown

Cancer cell international 25:160 PubMed40264142

2025

Taurochenodeoxycholic acid suppresses the progression of glioblastoma via HMGCS1/HMGCR/GPX4 signaling pathway in vitro and in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Xiumin Xue,Ziwan He,Furui Liu,Qian Wang,Zhichao Chen,Lin Lin,Danni Chen,Yinfeng Yuan,Zhihui Huang,Yongjie Wang

Cell death & disease 16:308 PubMed40240362

2025

IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Anbo Gao,Juan Zou,Tian Zeng,Mei Qin,Xing Tang,Ting Yi,Guangming Song,Jie Zhong,Yuhuan Zeng,Wenchao Zhou,Qin Gao,Qunfeng Zhang,Juan Zhang,Yukun Li

Nature communications 16:3312 PubMed40204713

2025

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

Applications

Unspecified application

Species

Unspecified reactive species

Diana Acosta Ingram,Emir Turkes,Tae Yeon Kim,Sheeny Vo,Nicholas Sweeney,Marie-Amandine Bonte,Ryan Rutherford,Dominic L Julian,Meixia Pan,Jacob Marsh,Andrea R Argouarch,Min Wu,Douglas W Scharre,Erica H Bell,Lawrence S Honig,Jean Paul Vonsattel,Geidy E Serrano,Thomas G Beach,Celeste M Karch,Aimee W Kao,Mark E Hester,Xianlin Han,Hongjun Fu

Heliyon 10:e37518 PubMed39323844

2024

Quercetin represses cholesterol metabolism and mitigates resistance to cisplatin in oral squamous cell carcinoma by regulating AGR2/AKT/SREBP2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jiao Wang,Peng Zhang,Ling Chen

Cell death and differentiation 30:1710-1725 PubMed37202505

2023

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Carina R Maier,Oliver Hartmann,Cristian Prieto-Garcia,Kamal M Al-Shami,Lisa Schlicker,Felix C E Vogel,Silke Haid,Kevin Klann,Viktoria Buck,Christian Münch,Werner Schmitz,Elias Einig,Bastian Krenz,Marco A Calzado,Martin Eilers,Nikita Popov,Mathias T Rosenfeldt,Markus E Diefenbacher,Almut Schulze

Molecular carcinogenesis 62:754-770 PubMed36920044

2023

Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fengjiao He,Qiong Liu,Huan Liu,Qian Pei,Hong Zhu

Frontiers in neurology 14:1023950 PubMed37006485

2023

Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology and tissue characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Guilherme Rossi Assis-Mendonça,Maria Carolina Pedro Athié,João Vitor Gerdulli Tamanini,Arethusa de Souza,Gabriel Gerardini Zanetti,Patrícia Aline Oliveira Ribeiro de Aguiar Araújo,Enrico Ghizoni,Helder Tedeschi,Marina Koutsodontis Machado Alvim,Vanessa Simão de Almeida,Welliton de Souza,Roland Coras,Clarissa Lin Yasuda,Ingmar Blümcke,André Schwambach Vieira,Fernando Cendes,Iscia Lopes-Cendes,Fabio Rogerio

Antioxidants (Basel, Switzerland) 12: PubMed36978970

2023

Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shuangxue Han,Zhijun He,Xia Hu,Xiaoqian Li,Kaixin Zheng,Yingying Huang,Peng Xiao,Qingguo Xie,Jiazuan Ni,Qiong Liu

International journal of molecular sciences 24: PubMed36835419

2023

ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuting Tang,Jincheng Ma,Pingping Su,Huifang Lei,Yao Tong,Liangzhi Cai,Shuxia Xu,Xiaodan Mao,Pengming Sun
View all publications
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