Anti-HMGCS2 antibody [EPR26978-41] - BSA and Azide free (Capture)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HMGCS2 also known as hydroxymethylglutaryl-CoA synthase 2 is an enzyme involved in ketogenesis. It catalyzes the conversion of acetyl-CoA to HMG-CoA an essential step in the production of ketone bodies. This enzyme has a molecular mass of approximately 57 kDa. HMGCS2 is mainly expressed in the liver and is located within the mitochondria where it works under controlled metabolic conditions.

Biological function summary

HMGCS2 activates the ketogenesis process which generates ketone bodies such as acetoacetate and β-hydroxybutyrate that serve as alternative energy sources when glucose is scarce. This enzyme is not known to be part of any larger protein complex. During fasting states or prolonged exercise the liver uptakes fatty acids and converts them into ketone bodies through HMGCS2 activity providing energy especially for organs like the brain and muscles.

Pathways

HMGCS2 functions in the ketogenesis and lipid metabolism pathways. It works alongside enzymes like HMG-CoA lyase which further processes HMG-CoA into acetoacetate a precursor for other ketone bodies. The interplay of HMGCS2 with fatty acid oxidation allows it to regulate energy homeostasis coordinating with enzymes such as carnitine palmitoyltransferase I which aids in transporting fatty acids into mitochondria for oxidation.

Associated diseases and disorders

HMGCS2 malfunctions or deficiencies relate to disorders such as hypoketotic hypoglycemia and hepatic encephalopathy. Disrupted activity can affect energy balance particularly during fasting impacting glucose homeostasis. Alterations in HMGCS2 expression or function can connect with proteins like medium-chain acyl-CoA dehydrogenase which plays roles in fatty acid metabolism disorders further complicating the metabolic landscape when HMGCS2 is impaired.