JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB117637

Anti-HMGN2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal HMGN2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HMGN2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HMG17, HMGN2, Non-histone chromosomal protein HMG-17, High mobility group nucleosome-binding domain-containing protein 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-HMGN2 antibody (AB117637)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HMGN2 antibody (AB117637)

Immunofluorescence analysis of HeLa cells, using 1/100 ab117637.The picture on the right is treated with the synthesized peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGN2 antibody (AB117637)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGN2 antibody (AB117637)

Human Thyroid, Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117637at 5μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human HMGN2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P05204

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HMGN2 also known as high mobility group nucleosome binding domain 2 is a small protein weighing approximately 10.1 kDa. It is a non-histone chromosomal protein that interacts directly with nucleosomes modulating chromatin structure and function. HMGN2 is widely expressed in various tissues and cells and it plays a role in gene regulation by affecting the chromatin compaction and transcriptional activity.
Biological function summary

HMGN2 influences cellular processes by binding to the nucleosome core particle within chromatin. It is a component of a dynamic chromatin complex that affects gene expression by remodeling chromatin structure making specific genomic regions more accessible to transcription machinery. HMGN2's interaction with nucleosomes can regulate a host of genes involved in growth and differentiation highlighting its role in modulating cellular functions.

Pathways

Chromatin remodeling and transcriptional regulation involve HMGN2 as a significant player. It participates in important pathways like gene expression regulation and cellular responses to DNA damage. HMGN2 interacts with proteins such as histones and other high mobility group proteins which orchestrate these pathways by modifying chromatin architecture and influencing transcription factor access.

HMGN2 shows relations to cancer and autoimmune diseases. Altered expression or mutations in HMGN2 can disrupt normal chromatin dynamics contributing to oncogenesis by deregulating genes involved in cell cycle control. Additionally autoimmune conditions may arise due to the immune system's aberrant response to misregulated HMGN2 affecting proteins such as histones that interact with this target. Understanding HMGN2's role in disease can offer insight into potential therapeutic strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
See full target information HMGN2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuropathology and experimental neurology 82:250-260 PubMed36592415

2023

MYB/MYBL1::QKI fusion-positive diffuse glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Yoon Suh,Kwanghoon Lee,Yu-Mi Shim,Ji Hoon Phi,Chul-Kee Park,Seung-Ki Kim,Seung Hong Choi,Hongseok Yun,Sung-Hye Park
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB248090

Anti-HMGN2 antibody [EPR7091] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGN2 antibody [EPR7091] - BSA and Azide free (AB248090)

  • 0
  • 0
Primary Antibodies

AB124997

Anti-HMGN2 antibody [EPR7091]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGN2 antibody [EPR7091] (AB124997)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB128925

Anti-GPCR GPR63 antibody [EPR7447]

RabMAb|Recombinant

Western blot - Anti-GPCR GPR63 antibody [EPR7447] (AB128925)

  • 0
  • 0
Primary Antibodies

AB133677

Anti-SOCS7 antibody [EPR8466]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS7 antibody [EPR8466] (AB133677)

  • 0
  • 0
Primary Antibodies

AB133570

Anti-5-HT2C Receptor antibody [EPR6487]

20ul selling size|RabMAb|Recombinant|Trial Size

Western blot - Anti-5-HT2C Receptor antibody [EPR6487] (AB133570)

  • 4
  • 3
Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

  • 4
  • 56

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com