Anti-HMW Cytokeratin antibody [34bE12]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

High molecular weight cytokeratins contribute significantly to the structural framework of cells. They form intermediate filaments that provide mechanical support and maintain cell shape. As part of this filament complex HMW Cytokeratins interacts with other cytoskeletal structures and adhesion molecules taking an active part in cellular dynamics and stability. These keratins also assist in the protection of epithelial cells from mechanical and non-mechanical stress.

Pathways

HMW Cytokeratins plays an important role in the keratinization pathway and epithelial cell differentiation processes. In the keratinization pathway these proteins interact with other keratins like KRT5 and KRT14 helping in the formation of resilient and tough surfaces on epithelial cells. In epithelial cell differentiation they are important in the regulation of cellular processes that define cell fate and tissue structure engaging with proteins like p63 which regulates gene expression in epithelial stem cells.