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AB200571

Anti-HN1L/L11 antibody

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(3 Publications)

Rabbit Polyclonal HN1L/L11 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human JPT2 aa 50-100.

View Alternative Names

C16orf34, HN1L, L11, JPT2, Jupiter microtubule associated homolog 2, Hematological and neurological expressed 1-like protein, HN1-like protein

2 Images
Western blot - Anti-HN1L/L11 antibody (AB200571)
  • WB

Supplier Data

Western blot - Anti-HN1L/L11 antibody (AB200571)

All lanes:

Western blot - Anti-HN1L/L11 antibody (ab200571) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 20 kDa

true

Exposure time: 10s

Immunoprecipitation - Anti-HN1L/L11 antibody (AB200571)
  • IP

Supplier Data

Immunoprecipitation - Anti-HN1L/L11 antibody (AB200571)

All lanes:

Immunoprecipitation - Anti-HN1L/L11 antibody (ab200571) at 0.4 µg/mL

Lane 1:

Immunoprecipitation using ab200571 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane) i from 293T cells prepared using NETN lysis buffer.

Lane 2:

Control IgG

Predicted band size: 20 kDa

true

Exposure time: 10s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human JPT2 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q9H910

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HN1L/L11 protein also known as Hematological and Neurological Expressed 1-Like has a molecular weight of approximately 19 kDa. It is expressed in various tissues including the liver and brain. Mechanically HN1L/L11 is involved in the regulation of cellular growth and proliferation although the exact mechanisms remain under investigation. Researchers often focus on its potential role in modulating gene expression and supporting cellular stress responses.
Biological function summary

HN1L/L11 plays a part in critical cellular functions that support homeostasis. This protein operates within cellular complexes that regulate transcription processes and it may interact with molecular machinery involved in stress adaptation. HN1L/L11's involvement in these essential cellular activities indicates its potential broader impact on maintaining cell survival and integrity in fluctuating environments.

Pathways

HN1L/L11 plays a role in signaling pathways linked to stress response and apoptosis regulation. Notably it is associated with the MAPK and the JAK/STAT pathways which are pivotal in cell survival and differentiation. Through these pathways HN1L/L11 shows interaction with other proteins such as JAK2 and STAT5 all contributing to the orchestration of cellular defense mechanisms under stress conditions.

Researchers have linked HN1L/L11 to various cancer types and neurodegenerative disorders. In cancer the protein's regulation of cell growth pathways implicates its potential role in tumor development and progression often in connection with proteins like p53. In neurodegenerative conditions aberrant expression or function of HN1L/L11 may contribute to neuronal stress and degeneration suggesting it could serve as a biomarker or therapeutic target in such diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed : 33758061, PubMed : 33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed : 33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed : 33758062).. (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.
See full target information JPT2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 13:1026 PubMed36476988

2022

HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Ting Zeng,Tian-Hao Deng,Zhen Liu,Jia-Rong Zhan,Yuan-Zhen Ma,Yuan-Yuan Yan,Xiao Sun,Ying-Hui Zhu,Yan Li,Xin-Yuan Guan,Lei Li

Journal of cell communication and signaling 17:121-135 PubMed35925508

2022

METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit.

Applications

Unspecified application

Species

Unspecified reactive species

Qiong Wu,Qingqing Hu,Yanan Hai,Yandong Li,Yong Gao

iScience 25:104405 PubMed35633940

2022

Construction of tissue-engineered nucleus pulposus by stimulation with periodic mechanical stress and BMP-2.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Liu,Gong-Ming Gao,Kai-Yuan Yang,Lu-Ming Nong
View all publications
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