Anti-hnRNP G antibody [EPR16038] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Heterogeneous nuclear ribonucleoprotein G (hnRNP G) also referred to as RBMX is a protein involved in RNA binding and processing. It is a member of the hnRNP protein family recognized for its role in managing the intricate processes of RNA metabolism. hnRNP G has a mass of approximately 43 kDa and is widely expressed in various tissues. The protein typically resides in the nucleus but it can shuttle between the nucleus and cytoplasm a common feature in the hnRNP family aiding in its diverse functionality.

Biological function summary

HnRNP G influences mRNA splicing stability and transport. It does not operate in isolation; instead it is part of ribonucleoprotein complexes that include other hnRNPs that work collectively. This protein facilitates alternative splicing events contributing to the generation of different protein isoforms that are essential for cellular diversity and adaptation. The ability of hnRNP G to bind to RNA and participate in these cellular events highlights its significance in regulatory processes.

Pathways

HnRNP G plays a role in the regulation of gene expression. It is an important player in the alternative splicing pathway affecting the diversity of mRNA products. hnRNP G interacts with the splicing machinery and can influence splice site selection. This protein is also associated with the DNA damage response pathway where it interacts with other proteins such as BRCA1 particularly under stress conditions that require enhanced DNA repair mechanisms.

Associated diseases and disorders

HnRNP G has connections to certain types of cancer and neurological disorders. Altered expression of hnRNP G is observed in breast cancer suggesting its role in tumor progression and gene regulation disruptions. Additionally changes in hnRNP G activity have been associated with neurodegenerative diseases like spinal muscular atrophy. In these contexts hnRNP G interfaces with proteins such as SMN1 linking its expression and function to disease outcomes and offering potential avenues for therapeutic intervention.