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AB28204

Anti-HODE antibody

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(1 Publication)

Goat Polyclonal HODE antibody. Suitable for ELISA, RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to HODE.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

ELISA, RIA

applications

Specificity

REACTIVITY: HAPTEN REACTIVITY 9(±)-HODE 100.0% 9(S)-HODE 100.0% 9(R)-HODE 100.0% 13(S)-HODE 1.2% 13(R)-HODE 1.2% 9-oxo-ODE 1.2% 13-oxo-ODE 2.4% 11(S)-HETE 0.0% 15(S)-HETE 0.0% Linoleic Acid 0.0%

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Complementary Products

Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
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Primary Antibodies

AB140795

Anti-GPR91 antibody - Cytoplasmic domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR91 antibody - Cytoplasmic domain (AB140795)

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Primary Antibodies

AB86093

Anti-DRIM antibody

Immunoprecipitation - Anti-DRIM antibody (AB86093)

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Primary Antibodies

AB205018

Anti-GAS41 antibody

Western blot - Anti-GAS41 antibody (AB205018)

  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
Ammonium sulphate fractionation.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target HODE which includes both 13-HODE and 9-HODE refers to hydroxyoctadecadienoic acids. These are oxidized derivatives of linoleic acid. HODEs have a molecular mass around 296.4 g/mol and are found throughout various tissues in the body including the cellular membranes of inflammatory cells and tissues involved in lipid metabolism. They play key roles in oxidative stress responses and are expressed in cells where lipoxygenase enzymes operate converting linoleic acid to HODE.
Biological function summary

Hydroxyoctadecadienoic acids serve as signaling molecules. They are involved in modulating inflammatory responses and maintaining cellular homeostasis. HODEs do not form part of a classical protein complex but interact with various receptors and enzymes to execute their biological function. They contribute to cell signaling pathways that regulate the body's response to cellular damage and inflammation.

Pathways

HODEs participate in the arachidonic acid metabolism pathway. This pathway involves important enzymes like 15-lipoxygenase which catalyzes the oxidation of linoleic acid to form HODEs. This process influences the production of other signaling molecules like leukotrienes and prostaglandins which are critical for inflammatory response regulation. HODEs also interact with peroxisome proliferator-activated receptors (PPARs) therefore influencing fatty acid metabolism and energy homeostasis.

HODEs are implicated in the development of atherosclerosis. They contribute to the formation of oxidized low-density lipoproteins (oxLDL) which are key in the pathogenesis of this cardiovascular disease. Additionally their involvement in inflammation connects HODEs to conditions like rheumatoid arthritis. In these disorders HODEs interact with proteins such as C-reactive protein and tumor necrosis factor-alpha (TNF-alpha) which are important in orchestrating inflammatory and immune responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HODE
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35409374

2022

Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jiongbiao Zhong,Joseph Chen,Anthony A Oyekan,Michael W Epperly,Joel S Greenberger,Joon Y Lee,Gwendolyn A Sowa,Nam V Vo
View all publications
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Product promise

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