Anti-Homeobox C10 antibody [HL1234]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXC10 also known as Homeobox C10 is a transcription factor that plays an important role in the regulation of gene expression. This protein weighing approximately 37 kDa belongs to the homeobox family and is involved in morphogenesis specifically in the development of the limbs and axial skeleton. Researchers have identified its expression in various tissues including the central nervous system and skeletal muscle. The presence of HOXC10 in these areas suggests its involvement in complex developmental processes and its importance in proper structural formation.

Biological function summary

HOXC10 participates in regulating cell differentiation and proliferation. It acts as a transcriptional regulator and part of the homeobox gene family which functions in determining cell fate and positional development. This factor does not function alone; it forms complexes with other proteins to exert its effects on target genes. By regulating the expression of other genes it supports the establishment of specific cellular phenotypes necessary for proper tissue and organ development.

Pathways

HOXC10 interacts with multiple signaling pathways including the Wnt and Hedgehog pathways which are critical for development and growth. In the Wnt pathway HOXC10 collaborates with other homeobox genes to influence gene expression necessary for proper cell positioning. It also relates closely with other HOX proteins such as HOXA1 and HOXD10 coordinating complex regulation processes that guide embryonic development and patterning.

HOXC10 has connections to several pathological conditions including cancers and neurological disorders. Aberrant expression of HOXC10 has been linked with breast cancer where it is believed to promote cancer cell proliferation and survival. Additionally changes in HOXC10 expression are associated with developmental disorders involving skeletal and neural defects. Proteins like HOXB7 and HOXD13 interact with HOXC10 showing their involvement in the regulation of pathways that when disrupted may lead to disease states. Understanding its role better could offer insights into targeted therapies for these conditions.