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AB73885

Anti-Homeobox protein cut-like 1 antibody

4

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal Homeobox protein cut-like 1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CUX1.

View Alternative Names

CUTL1, CUX1, Homeobox protein cut-like 1, CCAAT displacement protein, CDP/Cux p200, Homeobox protein cux-1, CDP

1 Images
Western blot - Anti-Homeobox protein cut-like 1 antibody (AB73885)
  • WB

Unknown

Western blot - Anti-Homeobox protein cut-like 1 antibody (AB73885)

All lanes:

Western blot - Anti-Homeobox protein cut-like 1 antibody (ab73885) at 1/500 dilution

Lane 1:

extracts from K562 cells at 20 µg

Lane 2:

extracts from K562 cells at 20 µg with immunizing peptide

Predicted band size: 77 kDa

Observed band size: 164 kDa,75 kDa,80 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CUX1. The exact immunogen used to generate this antibody is proprietary information.

P39880

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Homeobox protein cut-like 1 often abbreviated as CUX1 functions as a transcription factor involved in the regulation of gene expression. It has an approximate mass of 110 kDa. CUX1 localizes mainly in the nucleus and is widely expressed in various tissues with higher levels observed in the thymus spleen and testis. This protein plays a significant role in cell cycle progression particularly during the S phase where it aids in DNA replication and repair.
Biological function summary

CUX1 regulates the transcription of genes involved in cell proliferation and differentiation. It forms part of a larger transcriptional complex often interacting with other transcription factors and co-regulators to exert its effects. CUX1 influences several developmental processes including hematopoiesis and neuronal differentiation highlighting its broad involvement in cellular function and development.

Pathways

CUX1 interacts within key signaling pathways such as the Wnt signaling and TGF-beta pathways. It plays a role in modulating the expression of genes controlled by these pathways impacting cell fate and proliferation. CUX1 often cooperates with other proteins such as SMADs in the TGF-beta pathway to execute complex regulatory functions. This partnership highlights the integrative role of CUX1 in cellular signaling networks that maintain homeostasis.

CUX1 has been linked to oncogenesis particularly in cancers such as breast cancer and leukemia. Alterations in CUX1 expression or function can lead to uncontrolled cell proliferation as seen in these cancers. Additionally CUX1 interacts with proteins like TP53 in cancer contexts modulating apoptosis and cellular stress responses. These interactions and effects demonstrate the pivotal involvement of CUX1 in the pathogenesis of certain diseases making it a potential target for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.. CDP/Cux p110. Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
See full target information CUX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 9:399 PubMed37891174

2023

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yunyun Chen,Kun Zhang,Rui Zhang,Zhuo Wang,Liang Yang,Tingting Zhao,Shihui Zhang,Yong Lin,Hongzhou Zhao,Yongpan Liu,Yuxuan Wei,Yijian Zhou,Jiaying Zhang,Xianzong Ye,Jing Zhao,Xinxin Li,Jianwen Que,Songlin Shi,Kuancan Liu

Frontiers in oncology 10:536072 PubMed33344221

2020

PIK3CA Is Regulated by CUX1, Promotes Cell Growth and Metastasis in Bladder Cancer Activating Epithelial-Mesenchymal Transition.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyu Wang,Jun Shang,Zhiqin Li,Huanhuan Li,Chufan Zhang,Kai He,Shikang Li,Wen Ju

Nature genetics 46:33-8 PubMed24316979

2013

Inactivating CUX1 mutations promote tumorigenesis.

Applications

WB

Species

Unspecified reactive species

Chi C Wong,Inigo Martincorena,Alistair G Rust,Mamunur Rashid,Constantine Alifrangis,Ludmil B Alexandrov,Jessamy C Tiffen,Christina Kober,Anthony R Green,Charles E Massie,Jyoti Nangalia,Stella Lempidaki,Hartmut Döhner,Konstanze Döhner,Sarah J Bray,Ultan McDermott,Elli Papaemmanuil,Peter J Campbell,David J Adams
View all publications
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Product promise

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