JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB88827

Anti-Homer1 antibody

5

(2 Reviews)

|

(1 Publication)

Mouse Polyclonal Homer1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOMER1.

View Alternative Names

SYN47, HOMER1, Homer protein homolog 1, Homer-1

2 Images
Western blot - Anti-Homer1 antibody (AB88827)
  • WB

Unknown

Western blot - Anti-Homer1 antibody (AB88827)

All lanes:

Western blot - Anti-Homer1 antibody (ab88827) at 1/500 dilution

All lanes:

rat brain tissue lysate at 50 µg

Predicted band size: 40 kDa

Observed band size: 39 kDa

false

Western blot - Anti-Homer1 antibody (AB88827)
  • WB

Unknown

Western blot - Anti-Homer1 antibody (AB88827)

All lanes:

Western blot - Anti-Homer1 antibody (ab88827) at 1/500 dilution

Lane 1:

Homer transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 40 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HOMER1.

Q86YM7

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column

Have you thought about this alternative?

AB184955

Anti-Homer1 antibody [EPR15309]

5
2 Reviews
View product

We’re constantly upgrading our range to offer the highest quality products. We have selected this alternative product for your review because it gives improved performance, is easier and more convenient to use, or is available faster.

style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Homer1 also known as HOMER is a scaffolding protein with a mass of approximately 45 kDa. It functions in organizing receptor signaling complexes notably interacting with metabotropic glutamate receptors (mGluRs) and certain transient receptor potential (TRP) channels. Homer1 exists mainly in the postsynaptic density of excitatory synapses in the brain indicating its strong expression in neuronal tissues. It has multiple isoforms with the isoform 1a often being highlighted in various research contexts.
Biological function summary

Homer1 plays an important role in synaptic plasticity and intracellular calcium signaling. As part of a complex Homer1 aids in linking mGluRs to other proteins stabilizing receptor signaling and contributing to the regulation of calcium homeostasis within the cell. This scaffolding action has implications for the modulation of signal transduction pathways that maintain neuronal communication and synaptic efficacy.

Pathways

Homer1 interacts significantly with the mGluR signaling pathway and the calcium signaling pathway. These interactions place Homer1 at a nexus of neuronal signal propagation. Related proteins in this context include the mGluR1 and mGluR5 which in sync with Homer1 form a network ensuring proper synaptic response to neurotransmitters. TRPC channels are also closely related as Homer1 helps modulate their activity through dynamic assembly with mGluR complexes.

Homer1 shows involvement in various neurological conditions such as schizophrenia and autism spectrum disorders. Abnormalities in Homer1 expression or function are linked to disrupted synaptic signaling which contributes to the pathophysiology of these disorders. Within these disease frameworks proteins like mGluR5 collaborate with Homer1 and serve as focal points in understanding the disrupted signaling mechanisms underlying these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed : 18218901).
See full target information HOMER1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 41:111766 PubMed36476872

2022

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.

Applications

Unspecified application

Species

Unspecified reactive species

Jens Stepan,Daniel E Heinz,Frederik Dethloff,Thomas Bajaj,Andreas Zellner,Kathrin Hafner,Svenja Wiechmann,Sarah Mackert,Yara Mecdad,Michael Rabenstein,Tim Ebert,Silvia Martinelli,Alexander S Häusl,Maximilian L Pöhlmann,Anke Hermann,Xiao Ma,Hermann Pavenstädt,Mathias V Schmidt,Alexandra Philipsen,Chris W Turck,Jan M Deussing,Bernhard Kuster,Michael C Wehr,Valentin Stein,Joachim Kremerskothen,Carsten T Wotjak,Nils C Gassen
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB232668

Anti-Homer1 antibody [EPR15309] - BSA and Azide free

primary-antibodies

homer1-antibody-epr15309-bsa-and-azide-free-ab232668

0

(0 reviews)

Alternative Product
Primary Antibodies

AB211415

Anti-Homer1 antibody

primary-antibodies

homer1-antibody-ab211415

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com