Anti-HOMER3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The HOMER3 protein also known as Homer protein homolog 3 or Vesl-3 functions mechanically as a scaffolding protein. This protein belongs to the Homer/Vesl family and weighs around 37 kDa. The HOMER3 protein is expressed mainly in the brain specifically in the cerebellum cortex and hippocampus. By interacting with other proteins it modulates synaptic signaling and contributes to synaptic structure and plasticity.

Biological function summary

Within the family of Homer proteins HOMER3 acts by linking surface receptors to intracellular calcium release channels. It is an essential component of the postsynaptic density where it forms multimeric complexes. These complexes serve as a bridge between ion channels and metabotropic glutamate receptors (mGluRs) therefore playing a significant role in synaptic transmission and plasticity. By facilitating this interaction HOMER3 influences processes like learning and memory.

Pathways

HOMER3 is involved in two important biological pathways: the calcium signaling pathway and the mGluR signaling pathway. In the calcium signaling pathway HOMER3 interacts with proteins such as inositol 145-trisphosphate receptors (IP3Rs) to regulate calcium release from intracellular stores. In the mGluR signaling pathway it associates with mGluRs which influence synaptic transmissions in neurons and manage many neurological processes. The interactions and pathways are vital for proper neuronal function and plasticity.

Associated diseases and disorders

HOMER3 has been connected to neurological diseases specifically schizophrenia and autism spectrum disorders. In schizophrenia altered HOMER3 expression can interact with proteins like dysbindin which impacts synaptic functions and neurotransmitter systems. In autism spectrum disorders changes in HOMER3-related pathways may affect mGluR signaling which is implicated in the synaptic deficits observed in these conditions. Understanding these connections can aid in developing targeted therapies for these neurological disorders.