JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB97438

Anti-HOMER3 antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Rabbit Polyclonal HOMER3 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Homer protein homolog 3 aa 50-300.

View Alternative Names

Homer protein homolog 3, Homer-3, HOMER3

1 Images
Western blot - Anti-HOMER3 antibody (AB97438)
  • WB

Unknown

Western blot - Anti-HOMER3 antibody (AB97438)

10% SDS PAGE

All lanes:

Western blot - Anti-HOMER3 antibody (ab97438) at 1/1000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Homer protein homolog 3 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q9NSC5

style
left-column

Complementary Products

Primary Antibodies

AB184955

Anti-Homer1 antibody [EPR15309]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homer1 antibody [EPR15309] (AB184955)

  • 5
  • 2
Primary Antibodies

AB62341

Anti-RFP antibody

Lab Essentials

Western blot - Anti-RFP antibody (AB62341)

  • 4
  • 23
Primary Antibodies

AB42355

Anti-HIV1 Nef antibody [3D12]

Western blot - Anti-HIV1 Nef antibody [3D12] (AB42355)

  • 4
  • 1
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HOMER3 protein also known as Homer protein homolog 3 or Vesl-3 functions mechanically as a scaffolding protein. This protein belongs to the Homer/Vesl family and weighs around 37 kDa. The HOMER3 protein is expressed mainly in the brain specifically in the cerebellum cortex and hippocampus. By interacting with other proteins it modulates synaptic signaling and contributes to synaptic structure and plasticity.
Biological function summary

Within the family of Homer proteins HOMER3 acts by linking surface receptors to intracellular calcium release channels. It is an essential component of the postsynaptic density where it forms multimeric complexes. These complexes serve as a bridge between ion channels and metabotropic glutamate receptors (mGluRs) therefore playing a significant role in synaptic transmission and plasticity. By facilitating this interaction HOMER3 influences processes like learning and memory.

Pathways

HOMER3 is involved in two important biological pathways: the calcium signaling pathway and the mGluR signaling pathway. In the calcium signaling pathway HOMER3 interacts with proteins such as inositol 145-trisphosphate receptors (IP3Rs) to regulate calcium release from intracellular stores. In the mGluR signaling pathway it associates with mGluRs which influence synaptic transmissions in neurons and manage many neurological processes. The interactions and pathways are vital for proper neuronal function and plasticity.

HOMER3 has been connected to neurological diseases specifically schizophrenia and autism spectrum disorders. In schizophrenia altered HOMER3 expression can interact with proteins like dysbindin which impacts synaptic functions and neurotransmitter systems. In autism spectrum disorders changes in HOMER3-related pathways may affect mGluR signaling which is implicated in the synaptic deficits observed in these conditions. Understanding these connections can aid in developing targeted therapies for these neurological disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed : 18218901).
See full target information Homer protein homolog 3
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e33344 PubMed39035486

2024

Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Min Luo,Cheng Zhao,Yanhua Zhao,Yin Wang,Peifeng Li

Cell death & disease 12:1103 PubMed34815380

2021

Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Pu,Wenchuan Li,Anmin Wang,Ya Zhang,Zebang Qin,Zuoming Xu,Jianchu Wang,Yan Lu,Qianli Tang,Huamei Wei

Cancer research 74:808-17 PubMed24322982

2013

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Bridgid E Hast,Erica W Cloer,Dennis Goldfarb,Heng Li,Priscila F Siesser,Feng Yan,Vonn Walter,Ning Zheng,D Neil Hayes,Michael B Major
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com