Anti-HOOK2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HOOK2 also known as "hook II" is a protein involved in microtubule binding and anchoring of cytoplasmic organelles. It has a molecular mass of approximately 85 kDa. HOOK2 is expressed in various tissue types including brain and testis and localizes to specific cell structures like the cytoplasm and centrosomes. This protein helps organize the microtubule network which is critical for maintaining cellular architecture and intracellular transport processes.

Biological function summary

HOOK2 plays a role in cellular processes through its involvement in the Hook protein family known for coordinating endosome dynamics. HOOK2 forms part of the dynein-dynactin complex where it links organelles to the microtubule network facilitating directed movement. This protein is essential for endosome positioning and possibly involved in ciliary function through its tethering role. It modulates the interactions with motor proteins and other accessory components necessary for cellular trafficking.

Pathways

HOOK2's function integrates into the intracellular transport and cilia assembly pathways. It associates with proteins like dynein a motor protein that moves along microtubules to mediate transport within cells. In the ciliogenesis pathway HOOK2 participates in the extension and maintenance of cilia small hair-like structures important for cell signaling. The precise coordination in these pathways is important for cell communication and maintaining cellular homeostasis.

Associated diseases and disorders

HOOK2 has connections to certain neurodegenerative diseases and ciliopathies due to its role in microtubule dynamics and cilia formation. Aberrations in HOOK2 function can disrupt cellular transport mechanisms leading to neurological disorders such as Alzheimer's disease. Altered interactions with proteins like dynein in ciliopathy contexts can result in defects in ciliary function impacting cellular signaling pathways and contributing to disease pathology. Understanding HOOK2’s interactions in these processes provides insights into its role in health and disease.