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AB106251

Anti-HOPX/HOD antibody

3

(5 Reviews)

|

(3 Publications)

Rabbit Polyclonal HOPX/HOD antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOPX.

View Alternative Names

HOD, HOP, LAGY, NECC1, OB1, HOPX, Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1

1 Images
Western blot - Anti-HOPX/HOD antibody (AB106251)
  • WB

Unknown

Western blot - Anti-HOPX/HOD antibody (AB106251)

All lanes:

Western blot - Anti-HOPX/HOD antibody (ab106251) at 1/500 dilution

All lanes:

Human fetal heart tissue lysate

Predicted band size: 8 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HOPX.

Q9BPY8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA, 0.184% Tris glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein HOPX also known as Homeodomain only protein is encoded by the HOPX gene. It is a small protein with a mass of approximately 8.5 kDa. HOPX is expressed in various tissues including cardiac myocytes epithelial tissues and stem cells. Known for its homeodomain-like structure HOPX does not bind DNA directly. Instead it influences transcription by interacting with other transcription factors and cofactors. The alternate name for HOPX is HOD and it serves as a reliable marker reflecting cellular differentiation and development.
Biological function summary

HOPX plays a role in regulating cell differentiation and tissue homeostasis. It acts without forming part of a larger protein complex primarily serving as a transcriptional regulator. This protein modulates the expression of genes critical for cell differentiation particularly in muscle and cardiac tissues. HOPX negatively regulates cell proliferation by modifying the transcription machinery influencing how cells enter mature states. Its role in differentiation makes it significant in both embryonic development and maintaining the integrity of adult cells.

Pathways

HOPX is significantly involved in the Wnt signaling pathway an important pathway in regulating cell fate across developmental stages. It modulates this pathway by interacting with proteins like β-catenin ensuring proper differentiation of various cell types. Another relevant pathway that includes HOPX is the BMP signaling pathway. Through this pathway HOPX contributes to osteogenesis and chondrogenesis working alongside proteins like SMADs which are effectors in the BMP pathway.

HOPX has implications in cancer and heart disease. Aberrant HOPX expression can lead to cancer progression particularly in lung and colon cancers. It seems to act as a tumor suppressor and its interactions with proteins like p53 highlight its role in cancer biology. Additionally HOPX's regulation in cardiac development links it to congenital heart defects when mutations or misregulation occur. Understanding HOPX's interactions in these contexts offers potential therapeutic insights.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed : 27708256).
See full target information HOPX
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

EMBO reports 25:4433-4464 PubMed39256596

2024

Terminal α1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions.

Applications

Unspecified application

Species

Unspecified reactive species

Saray Chen,Dana Hayoun-Neeman,Michal Nagar,Sapir Pinyan,Limor Hadad,Liat Yaacobov,Lilach Alon,Liraz Efrat Shachar,Tair Swissa,Olga Kryukov,Orly Gershoni-Yahalom,Benyamin Rosental,Smadar Cohen,Rachel G Lichtenstein

Autophagy 20:1032-1053 PubMed37978868

2023

Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair.

Applications

Unspecified application

Species

Unspecified reactive species

Man J Livingston,Ming Zhang,Sang-Ho Kwon,Jian-Kang Chen,Honglin Li,Santhakumar Manicassamy,Zheng Dong

Frontiers in toxicology 4:840606 PubMed35832493

2022

A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System.

Applications

Unspecified application

Species

Unspecified reactive species

Arunima Sengupta,Nuria Roldan,Mirjam Kiener,Laurène Froment,Giulia Raggi,Theo Imler,Lea de Maddalena,Aude Rapet,Tobias May,Patrick Carius,Nicole Schneider-Daum,Claus-Michael Lehr,Marianna Kruithof-de Julio,Thomas Geiser,Thomas Michael Marti,Janick D Stucki,Nina Hobi,Olivier T Guenat
View all publications
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Product promise

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