AB168179

Anti-HOXA1 antibody

Name: Anti-HOXA1 antibody (ab168179) | Abcam
Brand: Abcam Limited
SKU: AB168179

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(4 Publications)

Mouse Polyclonal HOXA1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOXA1.

View Alternative Names

HOX1F, HOXA1, Homeobox protein Hox-A1, Homeobox protein Hox-1F

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

Immunofluorescent analysis of HeLa cells labeling HOXA1 with ab168179 at 10 µg/ml.

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Western blot - Anti-HOXA1 antibody (AB168179)

All lanes:

Western blot - Anti-HOXA1 antibody (ab168179) at 1 µg/mL

Lane 1:

HOXA1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat anti-Mouse IgG HRP at 1/2500 dilution

Predicted band size: 36 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HOXA1.

P49639

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA1 also known as homeobox protein Hox-A1 is a transcription factor composed of 36 kDa. It contains a conserved DNA-binding domain known as the homeodomain. HOXA1 is encoded by the HOXA1 gene part of the Hox gene family responsible for regulating gene expression during early embryonic development. It gets expressed in specific regions during various developmental stages particularly contributing to the formation of the hindbrain and spinal cord. HOXA1 plays a significant role in controlling morphogenesis and differentiation processes.

Biological function summary

The transcription factor regulates critical developmental processes by influencing the expression of genes involved in anterior-posterior patterning. HOXA1 functions within a complex involving other HOX proteins ensuring precise spatial and temporal gene regulation during development. This regulation facilitates the establishment of distinct body structures and organ systems as the embryo progresses. HOXA1 participates in defining boundaries and segmental structures in embryonic tissues.

Pathways

HOXA1 impacts the retinoic acid signaling pathway and the Notch signaling pathway. It plays a significant role in the retinoic acid signaling axis influencing cell differentiation by modulating retinoid-responsive elements. In the Notch signaling pathway HOXA1 interacts with genes that control cell fate decisions often working in concert with other HOX proteins like HOXB1 and HOXD1. This involves activating downstream effectors vital for embryonic patterning and neurogenesis.

Researchers have linked HOXA1 dysregulation to certain congenital defects and cancers. It associates with congenital conditions such as Bosley-Salih-Alorainy syndrome characterized by abnormalities in facial and cranial nerves alongside problems with hearing and cardiovascular development. In cancer aberrant HOXA1 expression has been observed linking to breast cancer progression hinting at its involvement in tumorigenesis. These connections often involve interactions with proteins such as PAX1 in congenital abnormalities and ERBB2 in cancer highlighting the need for therapeutic explorations targeting these pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed : 16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).

See full target information HOXA1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:14515 PubMed40280985

2025

BPIFB4 rs4339026 A > G polymorphism impacts COPD susceptibility in the Kashi population, China.

Applications

Unspecified application

Species

Unspecified reactive species

Jingran Xu,Li Tao,Yanyan Shi,Hui Gong,Zulipikaer Abudureheman,Aifang Zheng,Xuemei Zhong,Lexin Xue,Xiaoguang Zou,Li Li

European journal of clinical investigation 51:e13487 PubMed33410156

2021

CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Lyu,Zhensheng Zhai,Zhengwen Hao,Haoruo Zhang,Jiefeng He

RNA biology 17:1613-1624 PubMed32372724

2020

Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Charannya Sozheesvari Subhramanyam,Qiong Cao,Cheng Wang,Zealyn Shi Lin Heng,Zhihong Zhou,Qidong Hu

Molecular medicine reports 19:1875-1882 PubMed30628697

2019

microRNA‑577 inhibits cell proliferation and invasion in non‑small cell lung cancer by directly targeting homeobox A1.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Men,Dandan Nie,Haiying Nie

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOXA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

Western blot - Anti-HOXA1 antibody (AB168179)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Secondary Antibodies

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Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise