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AB72591

Anti-HOXA11 antibody

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(6 Publications)

Rabbit Polyclonal HOXA11 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA11.

View Alternative Names

HOX1I, HOXA11, Homeobox protein Hox-A11, Homeobox protein Hox-1I

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-HOXA11 antibody (AB72591)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXA11 antibody (AB72591)

Immunofluorescence analysis of HUVEC cells, using ab72591, at 1/500 dilution, in the presence (right panel) or absence (left panel) of the immunising peptide.

Western blot - Anti-HOXA11 antibody (AB72591)
  • WB

Unknown

Western blot - Anti-HOXA11 antibody (AB72591)

All lanes:

Western blot - Anti-HOXA11 antibody (ab72591) at 1/500 dilution

Lane 1:

Extracts from RAW264.7 cells at 5 µg

Lane 2:

Extracts from RAW264.7 cells at 5 µg with immunising peptide

Predicted band size: 34 kDa

Observed band size: 30 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human HOXA11. The exact immunogen used to generate this antibody is proprietary information.

P31270

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA11 also known as homeobox A11 is a transcription factor involved in the regulation of gene expression. It belongs to the homeobox family and consists of about 33 kilodaltons. This target is expressed in various tissues including the uterus kidney and some parts of the nervous system. HOXA11 plays a significant role in the developmental process and cellular differentiation by binding to DNA sequences and influencing the transcriptional output of specific genes.
Biological function summary

HOXA11 is essential in limb and organ development such as kidneys and the female reproductive tract. As part of the regulatory gene family it interacts with other transcription factors and proteins forming complexes that are pivotal for developmental processes. HOXA11 contributes to the patterning of embryonic territories by specifying the identity and spatial arrangement of segments along the body axes. This transcription factor's activity highlights its importance in normal physiological development.

Pathways

HOXA11 functions are integral to the Wnt signaling pathway and the retinoic acid pathway. In these pathways HOXA11 can interact with proteins like Wnt which influences cellular processes such as proliferation differentiation and migration. The transcriptional regulation associated with HOXA11 is important for proper signaling within these pathways thereby impacting various developmental stages and processes.

HOXA11 has implications in congenital malformations and reproductive disorders. Mutations in HOXA11 may result in the malformation of limbs or conditions such as Mayer-Rokitansky-Küster-Hauser syndrome owing to its role in reproductive tract development. Additionally interactions with proteins like Wnt are also relevant since these interactions might contribute to the pathogenesis of developmental disorders highlighting the clinical significance of understanding HOXA11 function and regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXA11
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e27654 PubMed38524550

2024

Hypoxia/inflammation-induced upregulation of HIF-1α and C/EBPβ promotes nephroblastoma cell EMT by improving HOXA11-AS transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Shibo Zhu,Rui Zhou,Xiangliang Tang,Wen Fu,Wei Jia

Annals of translational medicine 10:1317 PubMed36660689

2023

Melatonin improves pregnancy outcomes in adenomyosis mice by restoring endometrial receptivity via NF-κB/apoptosis signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohong Guan,Dan Liu,Hong Zhou,Chaoqun Dai,Tao Wang,Yuan Fang,Yanping Jia,Kunming Li

Oxidative medicine and cellular longevity 2022:4102666 PubMed35633885

2022

Homeobox A1 Facilitates Immune Escape and Alleviates Oxidative Stress in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Fen Zhao,Hui Tian,Xinchao Liu,Yuanxiazi Guan,Ying Zhu,Peng Ren,Jianbo Zhang,Yinjun Dong,Lei Fu

Aging 13:17499-17515 PubMed34232917

2021

Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR-181c-5p/ZIC2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wei,Xiaoliang Zhao,Jiang Liu,Zhenfa Zhang

Experimental & molecular medicine 51:1-20 PubMed31757938

2019

Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Cheng Guo,Yi-Jun Yang,Jin-Fang Zheng,Jian-Quan Zhang,Min Guo,Xiang Yang,Xiang-Ling Jiang,Li Xiang,You Li,Huang Ping,Liu Zhuo

Oncotarget 8:9794-9805 PubMed28038461

2016

Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bingshu Xia,Ming Shan,Ji Wang,Zhenbin Zhong,Jingshu Geng,Xiaohui He,Tung Vu,Dekai Zhang,Da Pang
View all publications
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