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AB222304

Anti-HOXA2 antibody

1

(1 Review)

|

(1 Publication)

Rabbit Polyclonal HOXA2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HOXA2 aa 200-300.

View Alternative Names

HOX1K, HOXA2, Homeobox protein Hox-A2, Homeobox protein Hox-1K

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-HOXA2 antibody (AB222304)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HOXA2 antibody (AB222304)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for HOXA2 (green) using ab222304 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human HOXA2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

O43364

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Baboon": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Common marmoset": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA2 also known as homeobox A2 is a transcription factor belonging to the homeobox gene family. It has a molecular mass of approximately 27 kDa. This protein is primarily expressed in embryonic tissues especially in the developing brain spinal cord and branchial arches. HOXA2 plays an important role in regulating gene expression during embryonic development where it is involved in patterning different body structures by controlling cell fate and identity.
Biological function summary

HOXA2 functions in developmental processes acting as an important regulator in the formation of specific structures in the embryo. It operates as part of the homeotic gene complex which is essential for providing cells with positional information. HOXA2 establishes anterior-posterior identities and is particularly active in developing craniofacial regions. By orchestrating a network of downstream genes HOXA2 directs cellular differentiation and organization.

Pathways

HOXA2 is integral to the Hox gene cluster pathway which coordinates numerous aspects of embryonic developmental programs. It is deeply involved in the retinoic acid signaling pathway which influences morphogenesis and patterning during development. In these pathways HOXA2 works in concert with other Hox proteins such as HOXA1 and HOXA3 to modulate gene expression and help delineate segmental identities along the body axis.

Mutations or altered expression of HOXA2 have connections to craniofacial abnormalities and congenital disorders. Congenital disorders such as microtia and cleft palate link to disruptions in the function of HOXA2. In these cases the interaction between HOXA2 and other developmental proteins like the DLX and PAX families affects the formation of facial structures resulting in anatomical defects. Understanding these interactions provides insight into developmental pathologies and potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34029184

2021

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin-induced corpus luteum regression.

Applications

Unspecified application

Species

Unspecified reactive species

Dianrong Li,Jie Chen,Jia Guo,Lin Li,Gaihong Cai,She Chen,Jia Huang,Hui Yang,Yinhua Zhuang,Fengchao Wang,Xiaodong Wang
View all publications
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