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AB230879

Anti-HOXA3 antibody - C-terminal

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(8 Publications)

Rabbit Polyclonal HOXA3 antibody. C-terminal. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HOX1E, HOXA3, Homeobox protein Hox-A3, Homeobox protein Hox-1E

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA3 antibody - C-terminal (AB230879)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA3 antibody - C-terminal (AB230879)

Formalin-fixed, paraffin-embedded human testis tissue stained for HOXA3 using ab230879 at 1/50 dilution in immunohistochemical analysis.

Flow Cytometry (Intracellular) - Anti-HOXA3 antibody - C-terminal (AB230879)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-HOXA3 antibody - C-terminal (AB230879)

Intracellular flow cytometric analysis of HL-60 (Human promyelocytic leukemia cell line) cells, labeling HOXA3 with ab230879 at 1/10 dilution (green) compared to a negative control (blue). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Western blot - Anti-HOXA3 antibody - C-terminal (AB230879)
  • WB

Supplier Data

Western blot - Anti-HOXA3 antibody - C-terminal (AB230879)

All lanes:

Western blot - Anti-HOXA3 antibody - C-terminal (ab230879) at 1/1000 dilution

All lanes:

HL-60 (Human promyelocytic leukemia cell line) cell lysate at 35 µg

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, Flow Cyt (Intra)

applications

Immunogen

Synthetic Peptide within Human HOXA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O43365

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA3 also known as Homeobox A3 is a transcription factor involved in the regulation of gene expression. It serves key roles in the development and differentiation processes. With a molecular weight of approximately 35 kDa it is a member of the Homeobox gene family. HOXA3 expression occurs mainly in embryonic tissues predominantly in regions such as the hindbrain neural crest cells and vascular structures. The gene's expression is important for establishing the anterior-posterior axis and guiding proper morphogenetic processes during early development.
Biological function summary

HOXA3 contributes to the establishment of body maps by regulating target genes involved in developmental patterning. It acts as part of the homeotic gene complex which includes other HOX genes essential for segmental organization during embryogenesis. As a transcription factor HOXA3 binds to specific DNA sequences to control the expression of genes that direct the development of specific segments of the body. This function underpins its critical role in shaping the vertebrate body plan and influences the differentiation of cells within these segments.

Pathways

HOXA3 plays an integral role in pathways like the Hedgehog and Wnt signaling pathways which are essential for developmental processes. These pathways allow interactions with proteins such as HOXB and HOXD clusters reinforcing the segmental identity during embryo development. HOXA3 maintains proper regulation in these pathways ensuring correct gene expression patterns contributing to successful organogenesis and morphogenesis.

HOXA3 has been connected to congenital malformations and certain types of cancers. Mutations or dysregulation in its expression contribute to disorders such as congenital hypothyroidism. Moreover its aberrant expression links to tumor development where it may interplay with proteins like TP53 influencing cancer progression. Understanding the impact of HOXA3 in these pathways offers potential insights into developing targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXA3
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Molecular biomedicine 5:32 PubMed39138733

2024

Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

JiaoLin Yang,JinPeng Li,SuFen Li,YuTong Yang,HuanCheng Su,HongRui Guo,Jing Lei,YaLin Wang,KaiTing Wen,Xia Li,SanYuan Zhang,Zhe Wang

Discover. Oncology 14:108 PubMed37351805

2023

Development and validation of a predictive model in diagnosis and prognosis of primary glioblastoma patients based on Homeobox A family.

Applications

Unspecified application

Species

Unspecified reactive species

Zong-Qing Zheng,Gui-Qiang Yuan,Guo-Guo Zhang,Qian-Qian Nie,Zhong Wang

Scientific reports 13:9923 PubMed37337031

2023

HOXA3 accelerates wound healing in diabetic and aged non-diabetic mammals.

Applications

Unspecified application

Species

Unspecified reactive species

K Parella,K Moody,D Wortel,H Colegrove,J A Elser

Oncology reports 49: PubMed36799173

2023

HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kyung Jin Eoh,Dae Woo Lee,Eun Ji Nam,Jae In Kim,Hanna Moon,Sang Wun Kim,Young Tae Kim

Frontiers in immunology 13:1001381 PubMed36159801

2022

A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Zhirui Zeng,Chujiao Hu,Wanyuan Ruan,Jinjuan Zhang,Shan Lei,Yushi Yang,Pailan Peng,Feng Pan,Tengxiang Chen

Nutrition & diabetes 12:23 PubMed35443706

2022

Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tongtong Qiu,Xin Yang,Jingzhou Wang,Chongge Pan,Xiaolong Chu,Jianyu Xiong,Jianxin Xie,Yongsheng Chang,Cuizhe Wang,Jun Zhang

Journal of cellular and molecular medicine 25:3524-3536 PubMed33683826

2021

ARID1B/SUB1-activated lncRNA HOXA-AS2 drives the malignant behaviour of hepatoblastoma through regulation of HOXA3.

Applications

Unspecified application

Species

Unspecified reactive species

Gongbao Liu,Baihui Liu,Xiangqi Liu,Lulu Xie,Jiajun He,Jingjing Zhang,Rui Dong,Duan Ma,Kuiran Dong,Mujie Ye

Cell death & disease 11:917 PubMed33100331

2020

GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3.

Applications

Unspecified application

Species

Unspecified reactive species

Zhange Li,Honglin Xu,Xin Liu,Yang Hong,Han Lou,Heng Liu,Xue Bai,Lei Wang,Xia Li,Seth Mikaye Monayo,Justine Nyakango Mokembo,Nabanit Kumar Jha,Baofeng Yang,Yong Zhang
View all publications
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