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AB180217

Anti-HOXA6 antibody - N-terminal

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(1 Publication)

Goat Polyclonal HOXA6 antibody. N-terminal. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HOXA6 aa 1-50.

View Alternative Names

HOX1B, HOXA6, Homeobox protein Hox-A6, Homeobox protein Hox-1B

2 Images
Western blot - Anti-HOXA6 antibody - N-terminal (AB180217)
  • WB

Supplier Data

Western blot - Anti-HOXA6 antibody - N-terminal (AB180217)

All lanes:

Western blot - Anti-HOXA6 antibody - N-terminal (ab180217) at 0.01 µg/mL

Lane 1:

Mouse brain lysate in RIPA buffer at 35 µg

Lane 2:

Rat brain lysate in RIPA buffer at 35 µg

Predicted band size: 26 kDa

true

Western blot - Anti-HOXA6 antibody - N-terminal (AB180217)
  • WB

Supplier Data

Western blot - Anti-HOXA6 antibody - N-terminal (AB180217)

All lanes:

Western blot - Anti-HOXA6 antibody - N-terminal (ab180217) at 0.3 µg/mL

All lanes:

Human Olfactory bulb lysate in RIPA buffer at 35 µg

Predicted band size: 26 kDa

true

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human HOXA6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P31267

Specificity

ab180217 is expected to recognize isoform 1 (NP_004494.1) only.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab180217 ia purified from serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA6 also known as Homeobox protein Hox-A6 is a transcription factor belonging to the homeobox family with a molecular mass of approximately 26 kDa. This protein plays an important role in regulating gene expression morphogenesis and cellular differentiation. HOXA6 is primarily expressed in embryonic tissues especially during early developmental stages. It is also detected in certain adult tissues though at lower levels. The protein contributes to the formation of body plans during embryonic development by controlling the transcription of other genes.
Biological function summary

HOXA6 is involved in numerous critical developmental processes. As a part of the Hox gene complex it helps establish the anterior-posterior axis which is essential for proper body patterning and segmentation. This protein affects the specialization of cells and tissues contributing to the formation of organs. Moreover it plays a role in cell growth differentiation and apoptosis influencing diverse developmental pathways.

Pathways

HOXA6 integrates into pathways that shape embryonic development and organogenesis. It has a significant involvement in the Wnt signaling pathway which regulates cell fate decisions proliferation and migration. HOXA6 cooperates with proteins such as β-catenin a central player in the Wnt pathway. Additionally it interacts within the retinoic acid signaling pathway which affects the differentiation of various cell types and guides developmental trajectories.

Aberrant expression or mutation of the HOXA6 gene associates with cancer and developmental disorders. In particular gastric cancer shows a correlation with misregulated HOXA6 expression implicating its role in tumorigenesis. This ties HOXA6 to other proteins like MYC and BCL2 which are involved in cancer progression. Furthermore congenital malformations specifically limb abnormalities may arise from Hox gene dysregulation highlighting the importance of precise HOXA6 expression during development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXA6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 13:887822 PubMed35586041

2022

LINC00586 Represses ASXL1 Expression Thus Inducing Epithelial-To-Mesenchymal Transition of Colorectal Cancer Cells Through LSD1-Mediated H3K4me2 Demethylation.

Applications

Unspecified application

Species

Unspecified reactive species

Fengting Liu,Xiaofang Ma,Xiyun Bian,Chunyan Zhang,Xiaozhi Liu,Qiang Liu
View all publications
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Product promise

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