AB51235

Anti-HOXA7 antibody [743C1a]

Name: Anti-HOXA7 antibody [743C1a] (ab51235) | Abcam
Brand: Abcam Limited
SKU: AB51235
Price: 480 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal HOXA7 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXA7.

View Alternative Names

HOX1A, HOXA7, Homeobox protein Hox-A7, Homeobox protein Hox 1.1, Homeobox protein Hox-1A

1 Images

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Western blot - Anti-HOXA7 antibody [743C1a] (AB51235)

Western blot analysis of immunised recombinant protein

All lanes:

Western blot - Anti-HOXA7 antibody [743C1a] (ab51235)

Predicted band size: 25 kDa

Observed band size: 31 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

743C1a

Isotype

IgG1

Carrier free

Applications

applications

Immunogen

Recombinant Fragment Protein within Human HOXA7. The exact immunogen used to generate this antibody is proprietary information.

P31268

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

ab51235 was purified from culture supernatant of the hybridoma, cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA7 also known as Homeobox A7 is a transcription factor in the HOX family involved in regulating gene expression. This protein plays a role in developmental processes by binding to specific DNA sequences. It has a molecular weight of around 25 kDa. The expression of HOXA7 occurs in various tissues but it is especially abundant in embryonic tissues indicating its role in early developmental stages. The protein’s activity is important for proper cell differentiation and positioning within developing organisms.

Biological function summary

HOXA7 participates in controlling the developmental blueprint of an organism. It acts as a transcriptional regulator within the family of homeobox genes which functions in concert to ensure organs and tissues develop in the correct order and positions. HOXA7 forms a part of the larger homeobox complex interacting with other HOX proteins to coordinate the precise expression of target genes. Disruptions in its activity can lead to misregulation of these essential developmental processes.

Pathways

The mechanistic activities of HOXA7 relate closely to the Wnt signaling pathway and the cell differentiation pathway. It cooperates with other HOX proteins such as HOXA9 and HOXB4 to modulate gene expression during development. The Wnt signaling pathway in particular plays an important role in cell proliferation and axis patterning. Its interaction with Wnt-related proteins helps achieve spatial and temporal regulation of developmental genes contributing to the finely tuned process of morphogenesis.

Aberrations in HOXA7 expression or function link to certain cancers and developmental disorders. In leukemia researchers observe abnormal expressions of HOXA7 suggesting it may contribute to the dysregulation of cell proliferation associated with this disease. Additionally the protein relates to skeletal malformations where its dysfunction results in improper bone development. In these contexts HOXA7 may interact with proteins such as MEIS1 which can modify its activity and impact cellular outcomes associated with these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

See full target information HOXA7

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Neoplasma 67:825-833 PubMed32305054

2020

MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

S Wang,Y J Diao,B B Zhu

European review for medical and pharmacological sciences 23:716-723 PubMed30720179

2019

microRNA-144-3p suppresses human neuroblastoma cell proliferation by targeting HOXA7.

Applications

Unspecified application

Species

Unspecified reactive species

X-Y Cao,Z-Y Sun,L-J Zhang,M-K Chen,B Yuan

Nature cell biology 20:942-953 PubMed30013108

2018

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.

Applications

Unspecified application

Species

Unspecified reactive species

Hery Urra,Daniel R Henriquez,José Cánovas,David Villarroel-Campos,Amado Carreras-Sureda,Eduardo Pulgar,Emiliano Molina,Younis M Hazari,Celia M Limia,Sebastián Alvarez-Rojas,Ricardo Figueroa,Rene L Vidal,Diego A Rodriguez,Claudia A Rivera,Felipe A Court,Andrés Couve,Ling Qi,Eric Chevet,Ryoko Akai,Takao Iwawaki,Miguel L Concha,Álvaro Glavic,Christian Gonzalez-Billault,Claudio Hetz

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOXA7 antibody [743C1a]

Western blot - Anti-HOXA7 antibody [743C1a] (AB51235)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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