AB211521

Anti-HOXA7 antibody

Name: Anti-HOXA7 antibody (ab211521) | Abcam
Brand: Abcam Limited
SKU: AB211521
Price: 585 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal HOXA7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Hoxa7 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HOX1A, HOXA7, Homeobox protein Hox-A7, Homeobox protein Hox 1.1, Homeobox protein Hox-1A

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA7 antibody (AB211521)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA7 antibody (AB211521)

Immunohistochemical analysis of Human skin tissue labeling HOXA7 with ab211521 at 5 μg/ml. Heat mediated antigen retrieval used.

Supplier Data

Western blot - Anti-HOXA7 antibody (AB211521)

All lanes:

Western blot - Anti-HOXA7 antibody (ab211521) at 1/1000 dilution

All lanes:

WiDr whole cell lysate at 35 µg

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Rat Hoxa7 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P09634

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA7 also known as Homeobox A7 is a transcription factor in the HOX family involved in regulating gene expression. This protein plays a role in developmental processes by binding to specific DNA sequences. It has a molecular weight of around 25 kDa. The expression of HOXA7 occurs in various tissues but it is especially abundant in embryonic tissues indicating its role in early developmental stages. The protein’s activity is important for proper cell differentiation and positioning within developing organisms.

Biological function summary

HOXA7 participates in controlling the developmental blueprint of an organism. It acts as a transcriptional regulator within the family of homeobox genes which functions in concert to ensure organs and tissues develop in the correct order and positions. HOXA7 forms a part of the larger homeobox complex interacting with other HOX proteins to coordinate the precise expression of target genes. Disruptions in its activity can lead to misregulation of these essential developmental processes.

Pathways

The mechanistic activities of HOXA7 relate closely to the Wnt signaling pathway and the cell differentiation pathway. It cooperates with other HOX proteins such as HOXA9 and HOXB4 to modulate gene expression during development. The Wnt signaling pathway in particular plays an important role in cell proliferation and axis patterning. Its interaction with Wnt-related proteins helps achieve spatial and temporal regulation of developmental genes contributing to the finely tuned process of morphogenesis.

Aberrations in HOXA7 expression or function link to certain cancers and developmental disorders. In leukemia researchers observe abnormal expressions of HOXA7 suggesting it may contribute to the dysregulation of cell proliferation associated with this disease. Additionally the protein relates to skeletal malformations where its dysfunction results in improper bone development. In these contexts HOXA7 may interact with proteins such as MEIS1 which can modify its activity and impact cellular outcomes associated with these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

See full target information HOXA7

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Molecular biomedicine 5:32 PubMed39138733

2024

Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

JiaoLin Yang,JinPeng Li,SuFen Li,YuTong Yang,HuanCheng Su,HongRui Guo,Jing Lei,YaLin Wang,KaiTing Wen,Xia Li,SanYuan Zhang,Zhe Wang

Cancer cell international 22:88 PubMed35183163

2022

HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yunzhi Dang,Jiao Yu,Shuhong Zhao,Ximing Cao,Qing Wang

EBioMedicine 41:225-235 PubMed30737083

2019

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Bertolini,Andrea Terrasi,Cristina Martelli,Gabriella Gaudioso,Andrea Di Cristofori,Alessandra Maria Storaci,Miriam Formica,Paola Braidotti,Katia Todoerti,Stefano Ferrero,Manuela Caroli,Luisa Ottobrini,Thomas Vaccari,Valentina Vaira

EBioMedicine 41:214-224 PubMed30737087

2019

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Terrasi,Irene Bertolini,Cristina Martelli,Gabriella Gaudioso,Andrea Di Cristofori,Alessandra Maria Storaci,Miriam Formica,Silvano Bosari,Manuela Caroli,Luisa Ottobrini,Thomas Vaccari,Valentina Vaira

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOXA7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA7 antibody (AB211521)

Western blot - Anti-HOXA7 antibody (AB211521)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise