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AB168279

Anti-HOXB1 antibody

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(2 Publications )

Mouse Polyclonal HOXB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOXB1.

View Alternative Names

HOX2I, HOXB1, Homeobox protein Hox-B1, Homeobox protein Hox-2I

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-HOXB1 antibody (AB168279)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXB1 antibody (AB168279)

Immunofluorescence analysis of HeLa cells labeling HOXB1 with ab168279 at 10μg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HOXB1.

P14653

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Primary Antibodies

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Primary Antibodies

AB284782

Anti-HOXB5 antibody [EP2827] - BSA and Azide free

RabMAb|Recombinant

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXB1 also known as Homeobox B1 is a transcription factor that plays an important role in early developmental processes. It belongs to the homeobox family and has a molecular weight of about 31 kDa. This protein is highly expressed in embryonic tissues particularly in the hindbrain region and is important for segmental identity in this area during development. As its expression is tightly regulated precise control ensures correct hindbrain patterning.
Biological function summary

HOXB1 functions as a regulator of gene expression during development. It acts in concert with other homeobox genes to establish and maintain the identity of specific cell types. HOXB1 is part of a larger complex of proteins that modulates chromatin structure aiding in transcriptional control. This interaction allows it to impact cellular differentiation processes dictating specific neuronal fates important for normal brain structure.

Pathways

HOXB1 operates within significant developmental pathways such as the retinoic acid signaling pathway which influences cell growth and differentiation. This protein also interacts with HOXA1 a related homeobox protein highlighting its role in gene regulatory networks that dictate neuronal patterning and differentiation. Such functional interactions place HOXB1 as an important node within the gene regulatory networks involved in development.

Improper expression or mutations in HOXB1 can lead to congenital facial malformations such as Bosley-Salih-Alorainy syndrome. Its involvement in this genetic disorder adds to its significance in craniofacial development. HOXB1 has also been associated with hindbrain malformations when expressed abnormally. Its interaction with other key developmental proteins like PAX6 further emphasizes its role in maintaining normal developmental processes and providing targets for understanding developmental disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
See full target information HOXB1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed36769256

2023

Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Telvin L Harrell,David J Davido,Andrea S Bertke

Molecular medicine reports 20:3388-3394 PubMed31432140

2019

Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival.

Applications

Unspecified application

Species

Unspecified reactive species

Fengju Li,Dingran Si,Xuejun Guo,Ningru Guo,Dandan Li,Liujing Zhang,Xianan Jian,Jiasheng Ma
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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