Rabbit Polyclonal HOXB2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXB2 aa 50-100.
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- Molecular medicine reports 25:2022HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuelian Yang,Yuanhe Tong,Wenxia Ye,Lifen ChenPubMed 35315492
- Open medicine (Warsaw, Poland) 16:1564-15822021Superenhancer-transcription factor regulatory network in malignant tumors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Liang,Linlin Li,Tian Xin,Binru Li,Dalin ZhangPubMed 34722892
- Molecular medicine reports 23:2020miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHailian Du,Ya'nan Bao,Chunying Liu,Anqiao Zhong,Yikai Niu,Xingping TangPubMed 33300085
- The Journal of international medical research 48:3000605198837312019miR-4324 functions as a tumor suppressor in colorectal cancer by targeting HOXB2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHailin Li,Guiling Zhu,Yanwei Xing,Yuekun Zhu,Daxun PiaoPubMed 31852342
- Neoplasma 66:386-3962019Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesX Chen,L Q Li,X Qiu,H WuPubMed 30784279
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human HOXB2 aa 50-100. The exact immunogen used to generate this antibody is proprietary information. Database link P14652
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Alternative names
HOX2H, HOXB2, Homeobox protein Hox-B2, Homeobox protein Hox-2.8, Homeobox protein Hox-2H, K8
Recommended products
Rabbit Polyclonal HOXB2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXB2 aa 50-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human HOXB2 aa 50-100. The exact immunogen used to generate this antibody is proprietary information. Database link P14652
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The HOXB2 protein also known as Homeobox B2 plays an important role in gene regulation during development. This protein belongs to the homeobox family which is characterized by the presence of a 60 amino acid residue helix-turn-helix motif that binds DNA. HOXB2 has a molecular mass of approximately 30 kDa. It is notably expressed in a variety of tissues including the central nervous system and axial skeleton where it contributes to the spatial specificity of cell differentiation.
- Biological function summary
HOXB2 influences the patterning of structures along the anterior-posterior axis in embryonic development. It does not function as a solitary protein but operates as part of a larger homeodomain protein complex. This protein participates in the regulation of genes responsible for morphogenesis. Its expression levels directly affect the identity and position of structures like the vertebrates and cranial nerves during early fetal development.
- Pathways
HOXB2 integrates its function within the retinoic acid signaling cascade which plays a pivotal role in embryogenesis. It connects with other members of the HOX family creating an orchestrated network of gene regulation that ensures proper spatial development. HOXB2's interaction with retinoic acid receptors enables the transmission of signals that dictate pattern formation and differentiation processes across various tissues.
- Associated diseases and disorders
Mutations or misregulation of HOXB2 have implications in congenital malformations and specific cancers such as leukemia. HOXB2 dysregulation in acute myeloid leukemia suggests its involvement in pathways alongside key proteins like HOXA9 and MEIS1. Such connections underline the protein’s influence in maintaining cellular identity and proliferation balance making HOXB2 a potential target for therapeutic strategies in developmental disorders and hematological malignancies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-HOXB2 antibody (ab220390)
Western blot analysis labeling HOXB2 with ab220390 at 0.04 ug/ml.
All lanes: Western blot - Anti-HOXB2 antibody (ab220390) at 0.04 µg/mL
Lane 1: HEK-293 (Human epithelial cell line from embryonic kidney) whole cell lysate
Lane 2: PC3 (Human prostate adenocarcinoma cell line) whole cell lysate
Predicted band size: 37 kDa
Immunocytochemistry/ Immunofluorescence - Anti-HOXB2 antibody (ab220390)
Immunofluorescent analysis of HEK 293 cells (PFA-fixed/Triton X-100 permeabilized) labeling HOXB2 with ab220390 at 4μg/ml (green).
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