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AB133701

Anti-HOXB9 antibody [EPR6950]

1

(1 Review)

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(5 Publications)

Rabbit Recombinant Monoclonal HOXB9 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

View Alternative Names

HOX2E, HOXB9, Homeobox protein Hox-B9, Homeobox protein Hox-2.5, Homeobox protein Hox-2E

2 Images
Western blot - Anti-HOXB9 antibody [EPR6950] (AB133701)
  • WB

Unknown

Western blot - Anti-HOXB9 antibody [EPR6950] (AB133701)

All lanes:

Western blot - Anti-HOXB9 antibody [EPR6950] (ab133701) at 1/1000 dilution

All lanes:

MCF7 cell lysate at 10 µg

Secondary

All lanes:

HRP labelled Goat anti Rabbit IgG at 1/2000 dilution

Predicted band size: 28 kDa

Observed band size: 28 kDa

false

OI-RD Scanning - Anti-HOXB9 antibody [EPR6950] (AB133701)
  • OI-RD Scanning

Unknown

OI-RD Scanning - Anti-HOXB9 antibody [EPR6950] (AB133701)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR6950

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HOXB9 protein also known as homeobox B9 acts as a transcription factor. This protein has a role in regulating gene expression during development. HOXB9 weighs approximately 27 kDa and it finds expression mainly in the lungs digestive system and hematopoietic cells. As part of the homeobox gene family HOXB9 contributes to the proper development and differentiation of tissues.
Biological function summary

HOXB9 helps regulate the growth and development of tissues and organs. It does not function alone but is part of a larger group of homeobox genes all of which work together for normal morphological development. This protein provides specificity in binding DNA sequences which in turn controls the expression of genes necessary for organogenesis.

Pathways

HOXB9 plays a role in the Wnt signaling pathway and the hedgehog signaling pathway. These pathways are essential for proper embryonic development. Within these pathways HOXB9 interacts with other proteins like β-catenin and Gli proteins supporting the regulation of cellular proliferation and differentiation.

HOXB9 shows a significant relation to breast cancer and lung adenocarcinoma. In these cancers HOXB9 expression levels often increase contributing to tumor progression. This protein interacts with others involved in cancer pathways such as VEGF and MMPs promoting angiogenesis and metastasis. Researchers closely study HOXB9 as a potential target for therapeutic intervention in such malignancies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXB9
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

The Journal of pathology 260:402-416 PubMed37272544

2023

The E2F1-HOXB9/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jinglin Zhang,Bonan Chen,Yifei Wang,Xiaoli Liu,Huan Yan,Kit Yee Wong,Aden Ky Chan,Alvin Hk Cheung,Chit Chow,Dazhi Xu,Shouyu Wang,Bing Huang,Li Liang,Huixing Ke,Chi Chun Wong,William Kk Wu,Alfred Sl Cheng,Jun Yu,Kwok Wai Lo,Ka Fai To,Wei Kang

Aging 12: PubMed33411683

2020

HOXB9 enhances the ability of lung cancer cells to penetrate the blood-brain barrier.

Applications

Unspecified application

Species

Unspecified reactive species

HongShan Zheng,ChenLong Li,ZhenZhe Li,KaiBin Zhu,HongBo Bao,JinSheng Xiong,Peng Liang

The Journal of investigative dermatology 138:1609-1619 PubMed29408459

2018

Regulation of Cancer Stem Cell Self-Renewal by HOXB9 Antagonizes Endoplasmic Reticulum Stress-Induced Melanoma Cell Apoptosis via the miR-765-FOXA2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jingrong Lin,Dongmei Zhang,Yongsheng Fan,Yulin Chao,Jinming Chang,Na Li,Linlin Han,Chuanchun Han

PloS one 10:e0122285 PubMed25860510

2015

The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.

Applications

WB

Species

Unspecified reactive species

Lav Darda,Fahad Hakami,Richard Morgan,Craig Murdoch,Daniel W Lambert,Keith D Hunter

Diabetes 63:2528-37 PubMed24622795

2014

PGC1α promoter methylation in blood at 5-7 years predicts adiposity from 9 to 14 years (EarlyBird 50).

Applications

Unspecified application

Species

Human

Rebecca Clarke-Harris,Terence J Wilkin,Joanne Hosking,Jonathan Pinkney,Alison N Jeffery,Brad S Metcalf,Keith M Godfrey,Linda D Voss,Karen A Lillycrop,Graham C Burdge
View all publications
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Product promise

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