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Rabbit Polyclonal HOXC10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus.


Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYD6
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-PICC/IF
Human
Tested
Tested
Tested
Mouse
Tested
Expected
Expected

Tested
Tested

Species

Mouse

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Target data

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Alternative names

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Rabbit Polyclonal HOXC10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYD6
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

HOXC10 participates in regulating cell differentiation and proliferation. It acts as a transcriptional regulator and part of the homeobox gene family which functions in determining cell fate and positional development. This factor does not function alone; it forms complexes with other proteins to exert its effects on target genes. By regulating the expression of other genes it supports the establishment of specific cellular phenotypes necessary for proper tissue and organ development.

Activity summary

HOXC10 also known as Homeobox C10 is a transcription factor that plays an important role in the regulation of gene expression. This protein weighing approximately 37 kDa belongs to the homeobox family and is involved in morphogenesis specifically in the development of the limbs and axial skeleton. Researchers have identified its expression in various tissues including the central nervous system and skeletal muscle. The presence of HOXC10 in these areas suggests its involvement in complex developmental processes and its importance in proper structural formation.

Pathways

HOXC10 interacts with multiple signaling pathways including the Wnt and Hedgehog pathways which are critical for development and growth. In the Wnt pathway HOXC10 collaborates with other homeobox genes to influence gene expression necessary for proper cell positioning. It also relates closely with other HOX proteins such as HOXA1 and HOXD10 coordinating complex regulation processes that guide embryonic development and patterning.

Associated diseases and disorders

HOXC10 has connections to several pathological conditions including cancers and neurological disorders. Aberrant expression of HOXC10 has been linked with breast cancer where it is believed to promote cancer cell proliferation and survival. Additionally changes in HOXC10 expression are associated with developmental disorders involving skeletal and neural defects. Proteins like HOXB7 and HOXD13 interact with HOXC10 showing their involvement in the regulation of pathways that when disrupted may lead to disease states. Understanding its role better could offer insights into targeted therapies for these conditions.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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4 product images

  • Immunocytochemistry/ Immunofluorescence - Anti-HOXC10 antibody (ab153904), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-HOXC10 antibody (ab153904)

    Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling HOXC10 with ab153904 at 1/2000 dilution. Alpha tubulin filaments were labeled red.

  • Western blot - Anti-HOXC10 antibody (ab153904), expandable thumbnail

    Western blot - Anti-HOXC10 antibody (ab153904)

    10% SDS PAGE

    All lanes: Western blot - Anti-HOXC10 antibody (AB153904) at 1/1000 dilution

    Lane 1: HeLa whole cell lysate at 30 µg

    Lane 2: HepG2 whole cell lysate at 30 µg

    Predicted band size: 38 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC10 antibody (ab153904), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC10 antibody (ab153904)

    Immunohistochemical analysis of paraffin-embedded HeLa xenograft tissue labeling HOXC10 with ab153904 at 1/500 dilution.

  • Western blot - Anti-HOXC10 antibody (ab153904), expandable thumbnail

    Western blot - Anti-HOXC10 antibody (ab153904)

    10% SDS PAGE

    All lanes: Western blot - Anti-HOXC10 antibody (AB153904) at 1/1000 dilution

    All lanes: Mouse muscle lysate at 50 µg

    Predicted band size: 32 kDa, 38 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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