Rabbit Polyclonal HOXC10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus.
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- International journal of oncology 64:2023mA‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYujuan Zhou,Qiang Huang,Chunping Wu,Ye Xu,Yang Guo,Xiaohui Yuan,Chengzhi Xu,Liang ZhouPubMed 38063205
- Heliyon 9:e210562023HOXC10 promotes esophageal squamous cell carcinoma progression by targeting FOXA3 and indicates poor survival outcome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoting He,Huiyu Wang,Runjie Wang,Yuting Li,Suqing Li,Xiufeng Cao,Junying XuPubMed 37876483
- Neoplasma 69:1303-13132022HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZheng-Hua Lin,Jia-Min He,San-Chuan Lai,Ning Ding,Ying Jiang,Xing-Kang He,Xiao-Sun Liu,Zhi-Hui HuangPubMed 36264773
- Journal of Cancer 13:3308-33172022HOXC10 Promotes Metastasis in Colorectal Cancer by Recruiting Myeloid-derived Suppressor Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiao Yu,Xiaojiao Chen,Shuhong Zhao,Jingchen Jing,Qing Wang,Yunzhi DangPubMed 36186898
- Bioengineered 13:14066-140792022MiR-4739 inhibits the malignant behavior of esophageal squamous cell carcinoma cells via the homeobox C10/vascular endothelial growth factor A/phosphatidylinositol 3-kinase/AKT pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaiqin Wu,Zhenchuan Liu,Chenglai Dong,Shaorui Gu,Lei Li,Wenli Wang,Yongxin ZhouPubMed 35730500
- Signal transduction and targeted therapy 7:532022Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYiyi Xi,Yuan Lin,Wenjia Guo,Xinyu Wang,Hengqiang Zhao,Chuanwang Miao,Weiling Liu,Yachen Liu,Tianyuan Liu,Yingying Luo,Wenyi Fan,Ai Lin,Yamei Chen,Yanxia Sun,Yulin Ma,Xiangjie Niu,Ce Zhong,Wen Tan,Meng Zhou,Jianzhong Su,Chen Wu,Dongxin LinPubMed 35210398
- Molecular medicine reports 24:2021Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Xie,Ran Chen,Liujia Yan,Zhangjun Jia,Guangshu Liang,Qin WangPubMed 34523692
- Discover. Oncology 12:122021HOXC10 promotes growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuanxin Miao,Weina Zhang,Su Liu,Xiangfeng Leng,Chunnan Hu,Hao SunPubMed 35201457
- Aging 12:19375-193982020HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYulong Peng et. al.PubMed 32897245
- Theranostics 10:3833-38482020Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYunzhi Dang et. al.PubMed 32206125
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYD6
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Tested | Expected | Expected |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Alternative names
HOX3I, HOXC10, Homeobox protein Hox-C10, Homeobox protein Hox-3I
Recommended products
Rabbit Polyclonal HOXC10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NYD6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HOXC10 also known as Homeobox C10 is a transcription factor that plays an important role in the regulation of gene expression. This protein weighing approximately 37 kDa belongs to the homeobox family and is involved in morphogenesis specifically in the development of the limbs and axial skeleton. Researchers have identified its expression in various tissues including the central nervous system and skeletal muscle. The presence of HOXC10 in these areas suggests its involvement in complex developmental processes and its importance in proper structural formation.
- Biological function summary
HOXC10 participates in regulating cell differentiation and proliferation. It acts as a transcriptional regulator and part of the homeobox gene family which functions in determining cell fate and positional development. This factor does not function alone; it forms complexes with other proteins to exert its effects on target genes. By regulating the expression of other genes it supports the establishment of specific cellular phenotypes necessary for proper tissue and organ development.
- Pathways
HOXC10 interacts with multiple signaling pathways including the Wnt and Hedgehog pathways which are critical for development and growth. In the Wnt pathway HOXC10 collaborates with other homeobox genes to influence gene expression necessary for proper cell positioning. It also relates closely with other HOX proteins such as HOXA1 and HOXD10 coordinating complex regulation processes that guide embryonic development and patterning.
- Associated diseases and disorders
HOXC10 has connections to several pathological conditions including cancers and neurological disorders. Aberrant expression of HOXC10 has been linked with breast cancer where it is believed to promote cancer cell proliferation and survival. Additionally changes in HOXC10 expression are associated with developmental disorders involving skeletal and neural defects. Proteins like HOXB7 and HOXD13 interact with HOXC10 showing their involvement in the regulation of pathways that when disrupted may lead to disease states. Understanding its role better could offer insights into targeted therapies for these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Immunocytochemistry/ Immunofluorescence - Anti-HOXC10 antibody (ab153904)
Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling HOXC10 with ab153904 at 1/2000 dilution. Alpha tubulin filaments were labeled red.
Western blot - Anti-HOXC10 antibody (ab153904)
10% SDS PAGE
All lanes: Western blot - Anti-HOXC10 antibody (ab153904) at 1/1000 dilution
Lane 1: HeLa whole cell lysate at 30 µg
Lane 2: HepG2 whole cell lysate at 30 µg
Predicted band size: 38 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC10 antibody (ab153904)
Immunohistochemical analysis of paraffin-embedded HeLa xenograft tissue labeling HOXC10 with ab153904 at 1/500 dilution.
Western blot - Anti-HOXC10 antibody (ab153904)
10% SDS PAGE
All lanes: Western blot - Anti-HOXC10 antibody (ab153904) at 1/1000 dilution
All lanes: Mouse muscle lysate at 50 µg
Predicted band size: 32 kDa, 38 kDa
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