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AB168368

Anti-HOXC13 antibody [EPR5626]

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(3 Publications)

Rabbit Recombinant Monoclonal HOXC13 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

HOX3G, HOXC13, Homeobox protein Hox-C13, Homeobox protein Hox-3G

2 Images
Immunoprecipitation - Anti-HOXC13 antibody [EPR5626] (AB168368)
  • IP

Unknown

Immunoprecipitation - Anti-HOXC13 antibody [EPR5626] (AB168368)

Detection of HOXC13 by Western Blot of Immunprecipitate. 293T cell lysate immunoprecipitated using ab168368 at 1/10 dilution; HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.

All lanes:

Immunoprecipitation - Anti-HOXC13 antibody [EPR5626] (ab168368)

Predicted band size: 35 kDa

false

Western blot - Anti-HOXC13 antibody [EPR5626] (AB168368)
  • WB

Unknown

Western blot - Anti-HOXC13 antibody [EPR5626] (AB168368)

All lanes:

Western blot - Anti-HOXC13 antibody [EPR5626] (ab168368) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 10 µg

Lane 2:

293T cell lysate at 10 µg

Lane 3:

Jurkat cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 35 kDa

false

  • Carrier free

    Anti-HOXC13 antibody [EPR5626] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR5626

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXC13 also known as Homeobox protein Hox-C13 is a transcription factor belonging to the homeobox gene family. This protein plays a significant role in regulating gene expression influencing cellular proliferation and differentiation. HOXC13 has a mass of approximately 37 kDa and is expressed in specific tissues including hair follicles the skin and certain regions of the central nervous system. The protein contains a homeodomain which allows it to bind DNA and control the transcription of genes essential for proper development.
Biological function summary

HOXC13 influences the development and maintenance of hair and skin by regulating the expression of keratin genes. As a member of the homeobox gene complex it contributes to the establishment of body plans during embryonic development. HOXC13 acts not alone but as part of transcriptional complexes that modify expression patterns of target genes ensuring proper structural attributes of tissues. Its activity impacts cellular differentiation impacting phenotypic characteristics such as hair texture and skin structure.

Pathways

HOXC13 plays a role in the Wnt signaling pathway and epidermal differentiation processes. It interacts with other HOX proteins such as HOXC8 and HOXD13 contributing to the regulation of gene networks involved in skin and appendage formation. These pathways dictate cellular fate ensuring coordinated development and function of keratinocytes in the epidermis as well as hair follicle morphogenesis and cycling.

Alterations in HOXC13 expression or function have been associated with ectodermal dysplasia and hair abnormalities. Mutations or dysregulation of this protein disrupt normal hair and skin development often leading to phenotypes of clinical importance like hypotrichosis. HOXC13 has been implicated in ectodermal dysplasias through its regulatory relationships with genes responsible for keratin synthesis highlighting its importance in integumentary system anomalies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).
See full target information HOXC13
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 26:439 PubMed37614427

2023

HOXC13 promotes cell proliferation, metastasis and glycolysis in breast cancer by regulating DNMT3A.

Applications

Unspecified application

Species

Unspecified reactive species

Hongrui Li,Pengcheng Gao,Haifeng Chen,Junjie Zhao,Xiangzhong Zhang,Ganggang Li,Liting Wang,Long Qin

Cell death & disease 14:398 PubMed37407582

2023

HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth.

Applications

Unspecified application

Species

Unspecified reactive species

Qicai Han,Penghui Yan,Ruipeng Song,Feifei Liu,Qing Tian

The British journal of nutrition 128:1050-1063 PubMed34632971

2021

The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chhinder P Sodhi,Andres J Gonzalez Salazar,Mark L Kovler,William B Fulton,Yukihiro Yamaguchi,Asuka Ishiyama,Sanxia Wang,Thomas Prindle,Mustafa Vurma,Tapas Das,Hongpeng Jia,Peng Lu,David J Hackam
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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