Anti-HoxC6 antibody [EPR7922(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HoxC6 also known as Homeobox C6 is a transcription factor that guides the formation of body structure during early development. The protein weighs approximately 25 kDa and plays an important role in sequencing and pattern formation in the embryonic development stages. It is expressed mainly in the central nervous system and developing tissues but also shows functionality in adult tissues. The activity of HoxC6 affects cellular differentiation and proliferation by regulating specific gene expression in these regions.

Biological function summary

The protein binds to DNA at specific sequences to activate or repress target gene transcription. This can affect cell fate and organ morphogenesis. HoxC6 associates with other Hox proteins and cofactors to form complexes that enhance or modify its regulatory functions. These interactions with cofactor proteins further strengthen its impact on developmental processes ensuring accurate tissue and organ formation.

Pathways

HoxC6 functions within pivotal developmental pathways such as the Hox gene regulatory network. This network synchronizes with signaling pathways like the Wnt and Notch controlling cell proliferation and differentiation. The collaboration with these pathways allows HoxC6 to manage gene cascades that maintain the correct body patterning. HoxB5 a related protein in the same pathway often interacts or shares similar roles coordinating to maintain orderly tissue patterning.

Associated diseases and disorders

Malfunction or mis-expression of HoxC6 links to certain cancers including leukemia and breast cancer. The protein's deregulation can lead to abnormal cell growth and differentiation. It works alongside proteins like Myc which also plays a central role in cancer to influence oncogenesis. Studies continue to explore HoxC6's involvement in these diseases considering its role in normal cellular development and potential therapeutic targeting.