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AB220856

Anti-HOXD1 antibody

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(3 Publications)

Rabbit Polyclonal HOXD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD1 aa 250 to C-terminus.

View Alternative Names

HOX4, HOX4G, HOXD1, Homeobox protein Hox-D1, Homeobox protein Hox-GG

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-HOXD1 antibody (AB220856)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HOXD1 antibody (AB220856)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized RT-4 cells labeling HOXD1 with ab220856 at 4 μg/ml (green).

Western blot - Anti-HOXD1 antibody (AB220856)
  • WB

Supplier Data

Western blot - Anti-HOXD1 antibody (AB220856)

All lanes:

Western blot - Anti-HOXD1 antibody (ab220856) at 1/100 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human plasma

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human HOXD1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9GZZ0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXD1 also known as Homeobox D1 is a transcription factor that plays a role in regulating gene expression. This protein has a mass of approximately 32 kDa. HOXD1 is part of the homeobox gene family which encodes transcription factors characterized by a specific sequence that binds DNA. HOXD1 shows expression in various tissues including the central nervous system and limbs during development. Its expression patterns suggest a role in the spatial and temporal regulation of developmental processes.
Biological function summary

HOXD1 contributes to the regulation of morphogenic development influencing the body layout along the anterior-posterior axis. It is not typically shown to be part of any larger protein complexes but interacts with other transcription factors to influence gene networks. During embryonic development HOXD1 orchestrates the activation and repression of target genes guiding proper morphogenesis and differentiation. This role is significant in setting positional identity and patterning of tissues.

Pathways

The HOXD1 protein participates in key developmental signaling pathways notably the Wnt signaling pathway. Wnt signaling affects cell proliferation polarity and migration making it critical during embryogenesis. HOXD1 collaborates with other homeobox genes like HOXA and HOXB clusters to ensure precise developmental patterning. The interactions among these homeobox proteins promote coordinated regulation of gene expression necessary for orderly development.

Alterations in HOXD1 expression have been linked to developmental disorders and certain cancers. Abnormal expression of HOXD1 may contribute to conditions such as synpolydactyly which affects limb development. Studies also suggest its potential involvement in various carcinomas due to its role in cell differentiation and proliferation. HOXD1's connections with other regulatory proteins like those in homeobox family suggest its mutation or dysregulation could influence similar associated disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
See full target information HOXD1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 52: PubMed39450540

2024

HOXD1 inhibits lung adenocarcinoma progression and is regulated by DNA methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Hu,Sijia Zhang,Xiaoyu Zhang,Hongyan Liu,Yutao Diao,Lianlian Li

Advanced biology 8:e2300276 PubMed37675827

2023

Human IPSC-Derived PreBötC-Like Neurons and Development of an Opiate Overdose and Recovery Model.

Applications

Unspecified application

Species

Unspecified reactive species

Xiufang Guo,Nesar Akanda,Gabriella Fiorino,Siddharth Nimbalkar,Christopher J Long,Alisha Colón,Aakash Patel,Patrick J Tighe,James J Hickman

The Journal of biological chemistry 296:100036 PubMed33410401

2021

The noncoding RNA BC200 associates with polysomes to positively regulate mRNA translation in tumor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Evan P Booy,Daniel Gussakovsky,Taegi Choi,Sean A McKenna
View all publications
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Product promise

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