AB138508

Anti-HOXD10 antibody [EPR9374]

RabMAb
Recombinant
What is this?

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(14 Publications)

Rabbit Recombinant Monoclonal HOXD10 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 14 publications.

View Alternative Names

HOX4D, HOX4E, HOXD10, Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E

2 Images

Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (AB138508)

Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (AB138508)

Intracellular flow cytometrical analysis of permeabilized HeLa cells with ab138508 antibody at a dilution of 1/100 (red) or a rabbit IgG negative (green).

Unknown

Western blot - Anti-HOXD10 antibody [EPR9374] (AB138508)

All lanes:

Western blot - Anti-HOXD10 antibody [EPR9374] (ab138508) at 1/1000 dilution

Lane 1:

ECV-304 cell lysate at 10 µg

Lane 2:

Fetal heart cell lysate at 10 µg

Lane 3:

Mouse heart cell lysate at 10 µg

Lane 4:

HeLa cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 38 kDa

false

Carrier free

Anti-HOXD10 antibody [EPR9374] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9374

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/100 - 1/500", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HOXD10 protein also known as Homeobox D10 is a member of the homeobox family of transcription factors that plays a mechanical role in regulating gene expression. This protein possesses a molecular mass of approximately 39 kDa. It primarily localizes in the nucleus where it binds to DNA and influences transcriptional activity during development and differentiation processes. HOXD10 expression occurs in tissues including the limbs and during various stages of embryonic development.

Biological function summary

The HOXD10 protein contributes to limb morphology and development. It functions independently but also interacts with other proteins and factors to control morphogenetic processes. HOXD10 influences cellular differentiation by modulating the expression of target genes necessary for specifying position and structure in developing tissues. Its expression is tightly regulated to ensure proper developmental patterns including in limb formation and spatial organization.

Pathways

The function of HOXD10 intricately links to the regulation of the developmental pathway known as the HOX gene pathway. This pathway coordinates with other pathways such as those controlling limb development to ensure the correct timing and positioning of structures during embryogenesis. Within these pathways other homeobox proteins like HOXA10 and HOXD11 have similar roles complementing and sometimes interacting with HOXD10 to orchestrate the precise patterning necessary for normal development.

Mutations or dysregulation of HOXD10 associate with limb malformations and possibly contribute to the development of some cancers like breast carcinoma. Its aberrant expression influences the activity of other critical proteins involved in cellular proliferation and differentiation such as p53 which affects tumorigenesis. Understanding the role and regulation of HOXD10 could provide insights into novel therapeutic strategies for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

See full target information HOXD10

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed40179015

2025

Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Liao,Ximing Zhou,Ling Wu,Yuyi Yang,Xiaohui Zhu,Hangyu Liao,Yujie Zhang,Weidong Lian,Feifei Zhang,Hui Wang,Yanqing Ding,Liang Zhao

iScience 27:111487 PubMed39759007

2025

miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Huang,Yidan Wang,Ruiyun Li,Yongmei Liu,Yuan Yang

Open medicine (Warsaw, Poland) 19:20230844 PubMed38756247

2024

HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Xu,Nana Lin

Environmental toxicology 39:2429-2438 PubMed38197552

2024

Ropivacaine combined with sorafenib attenuates hepatocellular carcinoma cell proliferation and metastasis by inhibiting the miR-224/HOXD10 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenting Wang,Tao Wang,Hongyun Lin,Desheng Liu,Peng Yu,Jing Zhang

Aging 15:10453-10472 PubMed37812190

2023

An immune signature to predict the prognosis of -wildtype glioma patients and guide immune checkpoint blockade therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Wenpeng Cao,Ping Sun,Shipeng Luo,Zhirui Zeng,Chaolun Xiao,Wenfeng Yu,Shan Lei

Cellular & molecular biology letters 26:20 PubMed34022794

2021

MiR-501 promotes tumor proliferation and metastasis by targeting HOXD10 in endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaomei Sun,Lingtong Hou,Chunping Qiu,Beihua Kong

Scientific reports 11:2844 PubMed33531596

2021

MiRNA10b-directed nanotherapy effectively targets brain metastases from breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Byunghee Yoo,Alana Ross,Pamela Pantazopoulos,Zdravka Medarova

The journal of obstetrics and gynaecology research 47:679-688 PubMed33258220

2020

Regulatory mechanism of miR-525-5p in over-invasion of trophoblast.

Applications

Unspecified application

Species

Unspecified reactive species

Min Zhang,Ping Li,Xuemei Mao,Hongyan Zhang

Molecular cancer 19:157 PubMed33172486

2020

Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.

Applications

Unspecified application

Species

Unspecified reactive species

Cunying Ma,Xiaoying Wang,Fenghua Yang,Yichen Zang,Jiansong Liu,Xinyi Wang,Xia Xu,Wenjuan Li,Jihui Jia,Zhifang Liu

American journal of translational research 11:2439-2446 PubMed31105850

2019

miR-501 promotes hemangioma progression by targeting .

Applications

Unspecified application

Species

Unspecified reactive species

Zhaofan Zeng,Sahua Liu,Junhong Cai,Zhenzhen Li,Hongfei Wu,Hao Chen,Yanjing Huang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOXD10 antibody [EPR9374]

Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (AB138508)

Western blot - Anti-HOXD10 antibody [EPR9374] (AB138508)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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