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Rabbit Recombinant Monoclonal HOXD10 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 10 publications.

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Images

Western blot - Anti-HOXD10 antibody [EPR9374] (AB138508), expandable thumbnail
  • Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (AB138508), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IPWBIHC-PICC/IFFlow Cyt (Intra)
Human
Not recommended
Tested
Not recommended
Not recommended
Tested
Mouse
Not recommended
Tested
Not recommended
Not recommended
Expected
Rat
Not recommended
Predicted
Not recommended
Not recommended
Predicted

Not recommended
Not recommended

Species

Mouse, Human, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/1000 - 1/10000

Notes

-

Species

Mouse

Dilution info

1/1000 - 1/10000

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Mouse, Human, Rat

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Mouse, Human, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100 - 1/500

Notes

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Target data

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Alternative names

Recommended products

Rabbit Recombinant Monoclonal HOXD10 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 10 publications.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Monoclonal

Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number

EPR9374

Purity

Tissue culture supernatant

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The HOXD10 protein also known as Homeobox D10 is a member of the homeobox family of transcription factors that plays a mechanical role in regulating gene expression. This protein possesses a molecular mass of approximately 39 kDa. It primarily localizes in the nucleus where it binds to DNA and influences transcriptional activity during development and differentiation processes. HOXD10 expression occurs in tissues including the limbs and during various stages of embryonic development.

Biological function summary

The HOXD10 protein contributes to limb morphology and development. It functions independently but also interacts with other proteins and factors to control morphogenetic processes. HOXD10 influences cellular differentiation by modulating the expression of target genes necessary for specifying position and structure in developing tissues. Its expression is tightly regulated to ensure proper developmental patterns including in limb formation and spatial organization.

Pathways

The function of HOXD10 intricately links to the regulation of the developmental pathway known as the HOX gene pathway. This pathway coordinates with other pathways such as those controlling limb development to ensure the correct timing and positioning of structures during embryogenesis. Within these pathways other homeobox proteins like HOXA10 and HOXD11 have similar roles complementing and sometimes interacting with HOXD10 to orchestrate the precise patterning necessary for normal development.

Associated diseases and disorders

Mutations or dysregulation of HOXD10 associate with limb malformations and possibly contribute to the development of some cancers like breast carcinoma. Its aberrant expression influences the activity of other critical proteins involved in cellular proliferation and differentiation such as p53 which affects tumorigenesis. Understanding the role and regulation of HOXD10 could provide insights into novel therapeutic strategies for these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-HOXD10 antibody [EPR9374] (ab138508), expandable thumbnail

    Western blot - Anti-HOXD10 antibody [EPR9374] (ab138508)

    All lanes: Western blot - Anti-HOXD10 antibody [EPR9374] (ab138508) at 1/1000 dilution

    Lane 1: ECV-304 cell lysate at 10 µg

    Lane 2: Fetal heart cell lysate at 10 µg

    Lane 3: Mouse heart cell lysate at 10 µg

    Lane 4: HeLa cell lysate at 10 µg

    Secondary

    All lanes: HRP labelled goat anti-rabbit at 1/2000 dilution

    Predicted band size: 38 kDa

  • Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (ab138508), expandable thumbnail

    Flow Cytometry (Intracellular) - Anti-HOXD10 antibody [EPR9374] (ab138508)

    Intracellular flow cytometrical analysis of permeabilized HeLa cells with ab138508 antibody at a dilution of 1/100 (red) or a rabbit IgG negative (green).

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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