Anti-HOXD10 antibody [EPR9374] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The HOXD10 protein also known as Homeobox D10 is a member of the homeobox family of transcription factors that plays a mechanical role in regulating gene expression. This protein possesses a molecular mass of approximately 39 kDa. It primarily localizes in the nucleus where it binds to DNA and influences transcriptional activity during development and differentiation processes. HOXD10 expression occurs in tissues including the limbs and during various stages of embryonic development.

Biological function summary

The HOXD10 protein contributes to limb morphology and development. It functions independently but also interacts with other proteins and factors to control morphogenetic processes. HOXD10 influences cellular differentiation by modulating the expression of target genes necessary for specifying position and structure in developing tissues. Its expression is tightly regulated to ensure proper developmental patterns including in limb formation and spatial organization.

Pathways

The function of HOXD10 intricately links to the regulation of the developmental pathway known as the HOX gene pathway. This pathway coordinates with other pathways such as those controlling limb development to ensure the correct timing and positioning of structures during embryogenesis. Within these pathways other homeobox proteins like HOXA10 and HOXD11 have similar roles complementing and sometimes interacting with HOXD10 to orchestrate the precise patterning necessary for normal development.

Associated diseases and disorders

Mutations or dysregulation of HOXD10 associate with limb malformations and possibly contribute to the development of some cancers like breast carcinoma. Its aberrant expression influences the activity of other critical proteins involved in cellular proliferation and differentiation such as p53 which affects tumorigenesis. Understanding the role and regulation of HOXD10 could provide insights into novel therapeutic strategies for these conditions.