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AB229234

Anti-HOXD13 antibody

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(2 Publications)

Rabbit Polyclonal HOXD13 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD13.

View Alternative Names

HOX4I, HOXD13, Homeobox protein Hox-D13, Homeobox protein Hox-4I

1 Images
Western blot - Anti-HOXD13 antibody (AB229234)
  • WB

Supplier Data

Western blot - Anti-HOXD13 antibody (AB229234)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-HOXD13 antibody (ab229234) at 1/1000 dilution

Lane 1:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 30 µg

Lane 2:

Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

Lane 3:

NCI-H929 whole cell lysate at 30 µg

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human HOXD13. The exact immunogen used to generate this antibody is proprietary information.

P35453

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXD13 also known as Homeobox D13 is a transcription factor encoded by the HOXD cluster of homeobox genes. It plays a significant role in the development and differentiation of limbs during embryogenesis. HOXD13 has a molecular mass of approximately 38 kDa. Researchers observe its expression in the developing limbs particularly in the distal limb buds which are important areas for digit formation.
Biological function summary

HOXD13 regulates the expression of genes that control limb formation and skeletal patterning. It functions as part of a larger complex of homeobox genes located on chromosome 2 in humans. This complex collaborates to establish the proper identities of segments along the proximal-distal axis of the limb working together with other HOX genes in the cluster to fine-tune developmental processes.

Pathways

HOXD13 is involved in the genetic regulatory networks that govern limb morphogenesis and digit specification. The Sonic hedgehog (Shh) signaling pathway significantly influences the expression of HOXD13 interacting with it to establish the gradient necessary for proper limb development. HOXD13 also associates with transcription factors like GLI3 within these pathways orchestrating the growth and spatial arrangement of the phalanges.

Mutations in HOXD13 link to synpolydactyly and hand-foot-genital syndrome. Synpolydactyly results from expanded polyalanine tracts in the HOXD13 protein leading to limb malformations with extra or webbed fingers and toes. This disorder also affects the function of related proteins such as HOXA13 highlighting the cooperative nature of homeobox genes in developmental disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed : 24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).
See full target information HOXD13
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 15:316 PubMed39304926

2024

MSC-extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

Applications

Unspecified application

Species

Unspecified reactive species

Hajer A Al Saihati,Arigue A Dessouky,Rabab F Salim,Islam Elgohary,Mohamed El-Sherbiny,Fares E M Ali,Mahmoud M A Moustafa,Dalia Shaheen,Nicholas Robert Forsyth,Omnia A Badr,Nesrine Ebrahim

Cell 181:1062-1079.e30 PubMed32386547

2020

Unblending of Transcriptional Condensates in Human Repeat Expansion Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Shaon Basu,Sebastian D Mackowiak,Henri Niskanen,Dora Knezevic,Vahid Asimi,Stefanie Grosswendt,Hylkje Geertsema,Salaheddine Ali,Ivana Jerković,Helge Ewers,Stefan Mundlos,Alexander Meissner,Daniel M Ibrahim,Denes Hnisz
View all publications
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