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AB270738

Anti-HPV16 E1+E4 antibody [HPV16 E1/E4]

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Mouse Monoclonal VE1 antibody. Suitable for IHC-P and reacts with Human papillomavirus samples. Immunogen corresponding to Recombinant Fragment Protein within Human papillomavirus type 16 E1 aa 1-50.

View Alternative Names

Replication protein E1, ATP-dependent helicase E1, E1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HPV16 E1+E4 antibody [HPV16 E1/E4] (AB270738)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HPV16 E1+E4 antibody [HPV16 E1/E4] (AB270738)

Formalin-fixed, paraffin-embedded human cervix tissue stained for HPV16 E1+E4 using ab270738 at 2 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HPV16 E1+E4 antibody [HPV16 E1/E4] (AB270738)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HPV16 E1+E4 antibody [HPV16 E1/E4] (AB270738)

Formalin-fixed, paraffin-embedded human cervix tissue stained for HPV16 E1+E4 using ab270738 at 2 μg/ml in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HPV16 E1/E4

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human papillomavirus

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Recombinant Fragment Protein within Human papillomavirus type 16 E4 aa 1-50. Database link P06922

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human papillomavirus": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from Bioreactor Concentrate.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
See full target information E1

Additional targets

E4
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