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AB20190

Anti-HPV16 E1+E4 antibody [TVG 403]

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(1 Publication)

Mouse Monoclonal VE1 antibody. Suitable for Flow Cyt, ELISA, IHC-Fr and reacts with Human papillomavirus type 16 samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Human papillomavirus type 16 E1.

View Alternative Names

Replication protein E1, ATP-dependent helicase E1, DNA 3'-5' helicase E1, E1, Protein E4, E1^E4, E4

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TVG 403

Isotype

IgG1

Carrier free

No

Reacts with

Human papillomavirus type 16

Applications

Flow Cyt, IHC-Fr, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Recombinant Protein within Human papillomavirus type 16 E4. Database link P06922

Epitope

E1/E4 protein is aa 36-41 of human papilloma virus type 16.

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Alternative Products

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Secondary Antibodies

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Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

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Primary Antibodies

AB283943

Anti-SARS-CoV-2 Spike Glycoprotein S1 antibody [EPR24852-116] - BSA and Azide free

RabMAb|Recombinant

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human papillomavirus type 16": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Product details

This antibody is of value in monitoring the progress of HPV infection from benign lesions to invasive cancer.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

ATP-dependent DNA 3'-5' helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
See full target information E1

Additional targets

E4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 74:10081-95 PubMed11024137

2000

The E1E4 protein of human papillomavirus type 16 associates with a putative RNA helicase through sequences in its C terminus.

Applications

Unspecified application

Species

Unspecified reactive species

J Doorbar,R C Elston,S Napthine,K Raj,E Medcalf,D Jackson,N Coleman,H M Griffin,P Masterson,S Stacey,Y Mengistu,J Dunlop
View all publications
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Product promise

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