AB17190
Anti-HPV16 E2 antibody [TVG 271]
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(1 Publication)
Mouse Monoclonal VE2 antibody. Suitable for ELISA, WB and reacts with Human papillomavirus type 16 samples. Cited in 1 publication.
View Alternative Names
Regulatory protein E2, E2
Reactivity data
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Product details
Properties and storage information
Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: 99.98% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
Product protocols
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Target data
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Publications (1)
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European journal of biochemistry 229:517-25 PubMed7744075
1995
The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2.
Applications
Unspecified application
Species
Unspecified reactive species
M H Hibma,K Raj,S J Ely,M Stanley,L Crawford
Product promise
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Associated Products
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Alternative Product
Primary Antibodies
AB17185
Anti-HPV16 E2 antibody [TVG 261]
primary-antibodies
hpv16-e2-antibody-tvg-261-ab17185
5
(3 reviews)
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