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AB20757

HRP Anti-Borrelia burgdorferi antibody

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(1 Publication)

Anti-Borrelia burgdorferi antibody conjugated to HRP is a rabbit polyclonal antibody suitable for ELISA, IHC-P, Western blot, and reacts with Lyme Disease Spirochete samples.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Reacts with

Borreliella burgdorferi

Applications

WB, IHC-P, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Bioactive

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Borrelia hermsii": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Borrelia parkeri": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Borreliella burgdorferi": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/20 - 1/200", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/200 - 1/1000", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Treponema pallidum": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

Purified IgG fraction of antiserum covalently coupled to a highly purified preparation of Horseradish Peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed.
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
Preservative: 0.002% Thimerosal (merthiolate) Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Borrelia burgdorferi known also as B. burgdorferi is a bacterium responsible for Lyme disease. It is a spirochete a type of bacteria distinguished by its corkscrew shape. This bacterium has a mass of approximately 1.5 million daltons. B. burgdorferi expresses surface proteins that have important roles in its survival and transmission including OspA and OspC which are key in interacting with host immune systems. These surface proteins allow Borrelia burgdorferi to adapt to different environments within tick vectors and mammalian hosts.
Biological function summary

The surface proteins of B. burgdorferi enable the bacterium to evade host immune responses. These components do not form part of a larger protein complex but they interact directly with host tissues to facilitate infection. B. burgdorferi's ability to alter its surface proteins through genetic recombination is a major factor in its persistence in host organisms. Its expression strategies enable it to adapt as a pathogen inside both the tick vector and mammalian hosts such as humans where it establishes chronic infections.

Pathways

Surface proteins like OspA and OspC play essential roles in the infection pathways used by Borrelia burgdorferi. Within the tick OspA enables adherence to tick midgut cells affecting transmission pathways when feeding. In mammals proteins like OspC assist the bacterium in evading the host's immune system contributing to pathways involving immune evasion and tissue infiltration. These protein interactions allow B. burgdorferi to exploit weaknesses in host defenses distinguishing this spirochete in bacterial pathogenesis.

Borrelia burgdorferi is directly related to Lyme disease a condition that if untreated can lead to severe neurological and arthritic symptoms. The surface protein OspC is particularly significant in early-stage Lyme disease and is a primary target for research into disease markers. In chronic cases Borrelia antibodies may not be effective leading to persistent infection. Additionally the relationship with other proteins like those in the host's immune pathways e.g. complement proteins is a current focus in understanding how B. burgdorferi achieves sustained infection in humans.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Borrelia burgdorferi

Alternative Names

B burgdorferi, B. burgdorferi, Lyme disease
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Stem cell research & therapy 13:350 PubMed35883190

2022

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed A Ghoneim,Mahmoud M Gabr,Ayman F Refaie,Sawsan M El-Halawani,Mohga M Al-Issawi,Batoul L Elbassiouny,Mai A Abd El Kader,Amani M Ismail,Mona F Zidan,Mary S Karras,Raghda W Magar,Sherry M Khater,Sylvia A Ashamallah,Mahmoud M Zakaria,Malgorzata Kloc
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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