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AB19175

HRP Anti-C Reactive Protein antibody

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(3 Publications)

Goat Polyclonal C Reactive Protein antibody - conjugated to HRP. Suitable for ICC, ELISA, WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

PTX1, CRP, C-reactive protein

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

WB, ICC, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

By immunoelectrophoresis and ELISA this antibody reacts specifically with human C Reactive Protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>(Colorimetric detection), 1/1000 - 30000 (Chemiluminescent detection).</p>" } } }
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Product details

Molar enzyme/antibody protein ratio is 4:1.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C-reactive protein (CRP) also known as CRP protein is an acute-phase protein with a molecular mass of approximately 25 kDa. It is primarily synthesized in the liver in response to cytokines. This protein appears in the blood where it binds to phosphocholine expressed on the surface of dead or dying cells. CRP is often used as a biomarker for inflammation in the body and its levels in human and canine (anti CRP used) blood samples are measured using assays like the CRP ELISA test or CRP ELISA kit.
Biological function summary

CRP plays a significant role in the innate immune system by recognizing foreign pathogens and damaged cells. It does not form part of a larger complex but itself can bind to specific ligands initiating the complement cascade. This activation enhances phagocytosis by macrophages contributing to the clearance of necrotic and apoptotic cells. The CRP protein therefore acts as a fast responder in the presence of inflammation making it a useful indicator for monitoring inflammatory diseases.

Pathways

CRP operates predominantly within the acute-phase response pathway. Its production is upregulated by cytokines such as IL-6 which connects it to inflammation-signaling pathways. CRP also interacts with the complement system bridging innate and adaptive immunity. Besides CRP could indirectly influence pathways involving other inflammatory proteins like serum amyloid A and haptoglobin creating a network of responses important for managing inflammation.

Elevated CRP levels are commonly associated with cardiovascular diseases and rheumatoid arthritis. In cardiovascular diseases CRP acts as a marker for atherosclerosis where the protein levels correlate with disease severity. It connects with other proteins involved in inflammatory processes such as fibrinogen to contribute to disease pathology. In rheumatoid arthritis CRP provides insights into disease activity helping in the assessment of treatment responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Displays several functions associated with host defense : it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
See full target information CRP
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Sensors (Basel, Switzerland) 18: PubMed29278402

2017

Synergistic Use of Gold Nanoparticles (AuNPs) and "Capillary Enzyme-Linked Immunosorbent Assay (ELISA)" for High Sensitivity and Fast Assays.

Applications

Unspecified application

Species

Unspecified reactive species

Wan-Joong Kim,Hyo Young Cho,Bongjin Jeong,Sangwon Byun,JaeDoo Huh,Young Jun Kim

Innate immunity 19:611-22 PubMed23475792

2013

Proteolytic cleavage of the long pentraxin PTX3 in the airways of cystic fibrosis patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yveline Hamon,Sébastien Jaillon,Christine Person,Jean-Louis Giniès,Erwan Garo,Barbara Bottazzi,Sarah Ghamrawi,Thierry Urban,Jean-François Subra,Jean-Philippe Bouchara,Alberto Mantovani,Pascale Jeannin,Yves Delneste

European journal of clinical nutrition 66:746-50 PubMed22510791

2012

Effect of vitamin D supplementation of low birth weight term Indian infants from birth on cytokine production at 6 months.

Applications

sELISA

Species

Unspecified reactive species

G Trilok-Kumar,H Arora,M Rajput,H Chellani,V Singh,J Raynes,S Arya,S Aggarwal,N Srivastava,H P S Sachdev,S Filteau
View all publications
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