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AB306288

HRP Anti-CD134 / OX40L receptor antibody [EPR23000-42]

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Rabbit Recombinant Monoclonal CD134 / OX40L receptor antibody - conjugated to HRP.

View Alternative Names

CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • Unconjugated

    Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 578 PE

    PE Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • 660 APC

    APC Anti-CD134 / OX40L receptor antibody [EPR23000-42]

  • Carrier free

    Anti-CD134 / OX40L receptor antibody [EPR23000-42] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23000-42

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Applications

Target Binding Affinity, Antibody Labelling

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

This conjugated primary antibody is "made to order" and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the Lightning-Link® conjugation technology, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.

For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.1% Proclin 300 Solution Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
See full target information TNFRSF4
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Complementary Products

Assay Kits

AB231926

Human OX40 ELISA Kit (TNFRSF4)

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Sandwich ELISA - Human OX40 ELISA Kit (TNFRSF4) (AB231926)

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Sandwich ELISA - Human OX40 ELISA Kit (TNFRSF4) (AB231926)

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Proteins & Peptides

AB307791

Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active)

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HPLC - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (AB307791)

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com