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AB111040

HRP Anti-Ochratoxin A antibody

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(1 Publication)

Rabbit Polyclonal Ochratoxin A antibody - conjugated to HRP. Suitable for cELISA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Ochratoxin A.
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Competitive ELISA - HRP Anti-Ochratoxin A antibody (AB111040)
  • cELISA

Unknown

Competitive ELISA - HRP Anti-Ochratoxin A antibody (AB111040)

Direct competitive inhibition ELISA using immobilized ab111040 at 1.5 ug/ml, and OA-labeled HRP (50 ng/mL). 50% inhibition occurred at 25 ng/mL of free Ochratoxin A in non-optimized conditions.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Applications

cELISA

applications

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Biochemicals

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "cELISA" : {"fullname" : "Competitive ELISA", "shortname":"cELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "cELISA-species-checked": "testedAndGuaranteed", "cELISA-species-dilution-info": "", "cELISA-species-notes": "<p></p>" } } }
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Product details

OA-NHS active ester, via acylation reaction. Ochratoxin A/HRP molar ratio, approximately 3:1.
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Properties and storage information

Form
Lyophilized
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6 - 8 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ochratoxin A is a mycotoxin that comes from mold species mainly Aspergillus and Penicillium. It is not a protein but acts through binding to serum proteins influencing biological processes. Ochratoxin A is classified as a secondary metabolite with a molecular weight of about 403.81 g/mol. It is expressed in food and beverages contaminated by fungal growth and also can be detected in human plasma when ingested. The presence of ochratoxin A leads to potential exposure risk through consumption of contaminated food products.
Biological function summary

Ochratoxin A exerts its effects by interfering with several cellular processes in the body particularly affecting kidney and liver function. Ochratoxin A affects protein synthesis and might disrupt DNA synthesis causing cellular stress and damage. It can also show interactions with cell membrane transporters and enzymes leading to altered redox balance inside cells. By these means ochratoxin A persistence in the body contributes to the toxicological effects that are studied under toxicology and pharmacology.

Pathways

Ochratoxin A participates in modulation of pathways involving oxidative stress and apoptosis. It interacts with key regulators in these pathways like cytochrome P450 enzymes which play a role in detoxification. Another impacted pathway is the aryl hydrocarbon receptor (AhR) signaling pathway which ochratoxin A might activate leading to changes in cellular metabolism and growth. These interactions suggest a connection with proteins like CYP1A1 known for involvement in drug metabolism and response to xenobiotics.

Ochratoxin A has a strong association with kidney-related diseases particularly nephrotoxicity which can lead to chronic kidney disease (CKD). It is also linked with liver dysfunction as the liver is a primary site of detoxification and metabolism. The presence of ochratoxin A can adversely affect proteins such as albumin which helps transport toxins in the blood and can signal the onset of these conditions. Understanding the impact of ochratoxin A on kidney and liver functions is vital in addressing risks related to mycotoxin exposure in humans.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Ochratoxin A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Viruses 15: PubMed36851534

2023

Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Cláudia Calvielli Castelo Branco,Emily Araujo De Oliveira,Nátalli Zanete Pereira,Ricardo Wesley Alberca,Amaro Nunes Duarte-Neto,Luiz Fernando Ferraz Da Silva,Fernanda Guedes Luiz,Naiura Vieira Pereira,Mirian Nacagami Sotto,Naiara Naiana Dejani,Patrícia Helen Carvalho Rondó,Elyzabeth Avvad-Portari,Zilton Farias Meira De Vasconcelos,Alberto José da Silva Duarte,Tamiris Azamor,Maria Notomi Sato
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Product promise

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