JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB181878

HRP Anti-Pepsin antibody - Azide free

Be the first to review this product! Submit a review

|

(1 Publication)

Goat Polyclonal Pepsin antibody - conjugated to HRP. Suitable for WB and reacts with Recombinant full length protein - Pig samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Pig PGA.

View Alternative Names

Pepsin A, PGA

1 Images
Western blot - HRP Anti-Pepsin antibody - Azide free (AB181878)
  • WB

Supplier Data

Western blot - HRP Anti-Pepsin antibody - Azide free (AB181878)

All lanes:

Western blot - HRP Anti-Pepsin antibody - Azide free (ab181878) at 1/1000 dilution

All lanes:

Pepsin protein at 0.1 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Applications

WB

applications

Immunogen

Native Full Length Protein corresponding to Pig PGA.

P00791

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
Preservative: 0.01% Gentamicin sulphate Constituents: 1% BSA, 0.88% Sodium chloride, 0.27% Tripotassium orthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pepsin is an enzyme with the main function of breaking down proteins into peptides in the stomach. Commonly known as a protease its molecular mass is approximately 35 kDa. This enzyme arises from its inactive precursor pepsinogen which activates in the acidic environment of the stomach. Expression predominantly occurs in the gastric chief cells. Pepsin remains a critical player in protein digestion with pepsin solutions often utilized for in vitro digestion studies.
Biological function summary

Pepsin fulfills an important role in the digestive process by breaking down larger protein molecules into smaller peptides facilitating nutrient absorption. It does not form part of a larger protein complex but operates independently within the gastric environment. Pepsin's enzymatic action targets specific peptide bonds ensuring efficient degradation of dietary proteins into absorbable forms. The specificity of its substrate binding ensures effective digestion and subsequent utilization of amino acids.

Pathways

Pepsin's activity integrates into proteolytic pathways particularly the catabolic processes in the gastrointestinal tract. It interacts with other digestive enzymes including trypsin and chymotrypsin which further hydrolyze peptides originated by pepsin. These interactions highlight its seamless fit in the digestive enzyme cascade optimized for effective protein turnover and nutrient release into the body. The pepsin pathway coordinates closely with the gastric and duodenal enzymatic processes.

Conditions such as peptic ulcers and Zollinger-Ellison syndrome link closely with excessive or dysregulated pepsin activity. Increased pepsin secretion in response to elevated gastric acid levels contributes to the degradation of the stomach lining aggravating ulcer formation. Alcohol-induced gastric mucosal damage also associates with heightened pepsin activity. Dysfunctional interactions involving pepsin and other gastric enzymes such as pepsinogen underline the pathological implications within these disorders.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
See full target information PGA

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 14:525-532 PubMed28693201

2017

S100P is associated with proliferation and migration in nasopharyngeal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yueyang Liu,Chengyu Wang,Xiaodong Shan,Jian Wu,Huanhai Liu,Haibin Liu,Jiping Zhang,Weihua Xu,Zhirong Sha,Jin He,Jingping Fan
View all publications

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com