AB38905

HRP Anti-Plasmodium aldolase antibody

Name: Anti-Plasmodium aldolase HRP antibody (ab38905) IgG | Abcam
Brand: Abcam Limited
SKU: AB38905
Price: 535 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(26 Publications)

Rabbit Polyclonal ALF antibody - conjugated to HRP. Suitable for ELISA, WB and reacts with Plasmodium falciparum samples. Cited in 26 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission

Carrier free

Reacts with

Plasmodium falciparum

Applications

WB, ELISA

applications

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plasmodium aldolase also known as ALD or aldolase MW is an important enzyme in the glycolytic pathway. It has a molecular weight of approximately 39 kDa. The enzyme catalyzes the reversible cleavage of fructose-16-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is important for energy production in the parasite Plasmodium which causes malaria. Plasmodium aldolase is expressed in various stages of the parasite's life cycle including the erythrocytic stage where the parasite infects red blood cells.

Biological function summary

Plasmodium aldolase plays a significant role in the survival and replication of the malaria parasite. It is not part of a larger protein complex but often associates with the cytoskeleton within the parasite facilitating its structural integrity and mobility. The enzyme's activity directly impacts the energy metabolism of Plasmodium making it essential for parasite survival and development in the host.

Pathways

Enzymes like Plasmodium aldolase operate within glycolytic and gluconeogenic pathways which are central to carbohydrate metabolism. In the glycolytic pathway aldolase sequentially interacts with proteins such as glyceraldehyde-3-phosphate dehydrogenase. Through its function in energy production aldolase indirectly supports various biosynthetic reactions and parasitic replication processes specific to Plasmodium.

Disturbances in Plasmodium aldolase function are directly linked to malaria one of the major global infectious diseases. The enzyme itself is a target for antimalarial drug development as inhibitors could potentially disrupt parasite energy metabolism leading to its death. Research also indicates a connection between aldolase and another protein lactate dehydrogenase which facilitates the parasite's anaerobic metabolism thereby contributing to its adaptability under different oxygen conditions in the human host.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Plasmodium aldolase

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Publications (26)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:142 PubMed39880906

2025

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization.

Applications

Unspecified application

Species

Unspecified reactive species

Junpei Fukumoto,Minako Yoshida,Suzumi M Tokuoka,Eri Saki H Hayakawa,Shinya Miyazaki,Takaya Sakura,Daniel Ken Inaoka,Kiyoshi Kita,Jiro Usukura,Hideo Shindou,Fuyuki Tokumasu

Proceedings of the National Academy of Sciences of the United States of America 122:e2403689122 PubMed39773028

2025

Mutational analysis of an antimalarial drug target, ATP4.

Applications

Unspecified application

Species

Unspecified reactive species

Swaksha Rachuri,Binod Nepal,Anurag Shukla,Aarti Ramanathan,Joanne M Morrisey,Thomas Daly,Michael W Mather,Lawrence W Bergman,Sandhya Kortagere,Akhil B Vaidya

eLife 13: PubMed38921824

2024

RNA polymerase III is involved in regulating virulence.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen Diffendall,Aurelie Claes,Anna Barcons-Simon,Prince Nyarko,Florent Dingli,Miguel M Santos,Damarys Loew,Antoine Claessens,Artur Scherf

iScience 27:109760 PubMed38726364

2024

M--M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids.

Applications

Unspecified application

Species

Unspecified reactive species

Sudipta Das,Anwesa Manna,Oindrila Majumdar,Lena Dhara

Pharmaceutics 15: PubMed37896200

2023

Epidrugs as Promising Tools to Eliminate Artemisinin-Resistant and Quiescent Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Thibaud Reyser,Lucie Paloque,Michel Nguyen,Jean-Michel Augereau,Matthew John Fuchter,Marie Lopez,Paola B Arimondo,Storm Hassell-Hart,John Spencer,Luisa Di Stefano,Françoise Benoit-Vical

ACS infectious diseases 9:1257-1266 PubMed37216290

2023

Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Irina Dobrescu,Elie Hammam,Jerzy M Dziekan,Aurélie Claës,Ludovic Halby,Peter Preiser,Zbynek Bozdech,Paola B Arimondo,Artur Scherf,Flore Nardella

Nature 612:528-533 PubMed36477538

2022

A transcriptional switch controls sex determination in Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

A R Gomes,A Marin-Menendez,S H Adjalley,C Bardy,C Cassan,M C S Lee,A M Talman

Life science alliance 6: PubMed36379669

2022

Discovery of RUF6 ncRNA-interacting proteins involved in immune evasion.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen M Diffendall,Anna Barcons-Simon,Sebastian Baumgarten,Florent Dingli,Damarys Loew,Artur Scherf

PLoS pathogens 18:e1010887 PubMed36223427

2022

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy James Russell,Erandi K De Silva,Valerie M Crowley,Kathryn Shaw-Saliba,Namita Dube,Gabrielle Josling,Charisse Flerida A Pasaje,Irene Kouskoumvekaki,Gianni Panagiotou,Jacquin C Niles,Marcelo Jacobs-Lorena,C Denise Okafor,Francisco-Javier Gamo,Manuel Llinás

Journal of medicinal chemistry 64:10403-10417 PubMed34185525

2021

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Flore Nardella,Ludovic Halby,Irina Dobrescu,Johanna Viluma,Corentin Bon,Aurélie Claes,Véronique Cadet-Daniel,Ambre Tafit,Camille Roesch,Elie Hammam,Diane Erdmann,Melissa Mairet-Khedim,Roger Peronet,Salah Mecheri,Benoit Witkowski,Artur Scherf,Paola B Arimondo

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

HRP Anti-Plasmodium aldolase antibody

Key facts

Host species

Clonality

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (26)

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