HRP Anti-Protein G antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Protein G plays a role in immune evasion by binding to the Fc region of IgG antibodies. This binding limits the immune system's ability to clear bacterial infections by preventing antibody-mediated opsonization and phagocytosis. Protein G can also form part of a larger immobilization complex in various experimental setups aiding in the purification and detection of antibodies. Protein G HRP conjugates further extend its utility in assay systems by enabling colorimetric detection.

Pathways

The interaction between protein G and IgG significantly impacts the immune response pathways. The binding of protein G to the Fc region of IgG interferes with pathways involving IgG-mediated activation of Fc receptors on immune cells. This affects signaling pathways like ADCC (antibody-dependent cellular cytotoxicity) and phagocytosis. Protein A is another bacterial protein that binds IgG similarly though it differs in affinity and subclass specificity.