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Goat Polyclonal Respiratory Syncytial Virus antibody - conjugated to HRP. Suitable for ELISA, IHC-P, Neut and reacts with Respiratory syncytial virus samples. Cited in 3 publications. Immunogen corresponding to Virus preparation containing Respiratory Syncytial Virus protein.

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Publications

Key facts

Isotype
IgG
Host species
Goat
Conjugation
HRP
Storage buffer

Preservative: 0.002% Thimerosal (merthiolate)
Constituents: PBS, 1% BSA

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Virus preparation containing Respiratory Syncytial Virus protein. The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ELISAIHC-PNeut
Respiratory syncytial virus
Expected
Expected
Expected

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Expected
Expected

Species
Respiratory syncytial virus
Dilution info
Use at an assay dependent concentration.
Notes

-

Associated Products

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Alternative names

Recommended products

Goat Polyclonal Respiratory Syncytial Virus antibody - conjugated to HRP. Suitable for ELISA, IHC-P, Neut and reacts with Respiratory syncytial virus samples. Cited in 3 publications. Immunogen corresponding to Virus preparation containing Respiratory Syncytial Virus protein.

Key facts

Isotype
IgG
Conjugation
HRP
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Virus preparation containing Respiratory Syncytial Virus protein. The exact immunogen used to generate this antibody is proprietary information.
Purity
IgG fraction
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Notes

Covalently coupled to a highly purified preparation of Horseradish Peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Respiratory Syncytial Virus (RSV) is a negative-sense single-stranded RNA virus known to cause respiratory infections. It belongs to the Paramyxoviridae family and is sometimes referred to by its alternate names like Human Orthopneumovirus. RSV is approximately 15 kb in size. It is predominantly expressed in the respiratory tract where it attacks epithelial cells leading to infection. The virus's ability to form a syncytium a large multinucleate cell is one of its mechanical strategies to aid in the spread across the host cells.

Biological function summary

The virus propagates efficiently within the host tissue leading to serious respiratory illness in infants and young children. RSV is not part of a specific complex but it engages host cellular machinery to promote its replication and prevent immune detection. The fusion (F) protein of RSV plays a critical role in mediating membrane fusion facilitating viral entry into the host cells. The involvement of viral proteins in modulating host immune responses is significant for the virus's life cycle.

Pathways

Respiratory infections caused by RSV connect to the host's immune signaling pathways including the toll-like receptor (TLR) pathways and the interferon response pathway. The interaction of RSV proteins with these pathways leads to an increased inflammatory response. Proteins such as the RSV G protein interface with the chemokine receptor pathway which helps in modulation of the immune system to allow viral persistence. These interactions demonstrate the virus's strategies to evade immune surveillance and promote infection.

Associated diseases and disorders

Respiratory syncytial virus is a major cause of bronchiolitis and pneumonia in infants and young children. The virus's activity in the respiratory tract contributes to severe inflammation and cell damage which can lead to hospitalization. Other proteins like RSV M protein are involved in virus assembly and budding and they passively influence disease progression by impacting viral load and the host's immune response. Understanding these interactions is important for developing therapeutic strategies including anti-RSV monoclonal antibodies like palivizumab (2F7) which target prominent viral components to prevent severe disease outcomes.

Product promise

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