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AB306426

HRP Anti-SEC22L1 antibody [EPR12335]

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Rabbit Recombinant Monoclonal SEC22B antibody - conjugated to HRP.

View Alternative Names

SEC22L1, SEC22B, Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ERS-24, ERS24

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12335

Isotype

IgG

Conjugation

HRP

Excitation/Emission
Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The rat recommendation is based on the WB results. We do not guarantee IHC-P for rat.

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Product details

This conjugated primary antibody is "made to order" and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the Lightning-Link® conjugation technology, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.

For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.1% Proclin 300 Solution Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEC22B also known as SEC22 homolog B is a membrane protein involved in vesicular trafficking within cells. It plays an important role in the transport between the endoplasmic reticulum (ER) and the Golgi apparatus. SEC22B belongs to the SNARE (soluble NSF attachment protein receptor) family with a molecular mass of approximately 29 kDa. It is expressed in various tissues with prominent presence in the immune system and neuronal tissues. The protein participates in the assembly of vesicle transport machinery important for proper cellular function and compartmentalization.
Biological function summary

SEC22B contributes to the fusion of transport vesicles with target membranes. It acts as part of a SNARE complex facilitating vesicle docking and subsequent membrane fusion through protein-protein interaction. In immune cells SEC22B is essential for antigen presentation. It regulates the trafficking of peptide-MHC complexes to the cell surface essential for adaptive immune response. In neurons the protein ensures efficient neurotransmitter release by managing vesicle cycling and synaptic vesicle fusion.

Pathways

SEC22B integrates into the vesicular transport and secretory pathways. It operates in the ER-Golgi transport route critical in maintaining cellular homeostasis and protein processing. The function of SEC22B involves interaction with other SNARE proteins like VAMP7 and SNAP23 forming SNARE complexes that drive membrane fusion events. This protein also influences the Golgi-to-ER retrograde transport contributing to the protein sorting pathway that recycles specific proteins back to the ER.

SEC22B links closely to immune-related conditions and neurodegenerative diseases. Disruption in SEC22B function can impact antigen presentation and immune system efficiency potentially contributing to autoimmune disorders. In neurological contexts altered SEC22B activity may interfere with neurotransmitter release possibly playing a role in conditions such as Alzheimer's disease. Connections with proteins like VAMP7 underline the importance of SEC22B in maintaining cellular integrity across different systems.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
See full target information SEC22B
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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