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AB136109

Anti-Hsd17b11 antibody

4

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Hsd17b11 antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human HSD17B11 aa 50-150.

View Alternative Names

DHRS8, PAN1B, SDR16C2, PSEC0029, UNQ207/PRO233, HSD17B11, Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase XI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, Short chain dehydrogenase/reductase family 16C member 2, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-HSD XI, 17betaHSDXI, CTCL-associated antigen HD-CL-03, retSDR2

1 Images
Western blot - Anti-Hsd17b11 antibody (AB136109)
  • WB

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Western blot - Anti-Hsd17b11 antibody (AB136109)

All lanes:

Western blot - Anti-Hsd17b11 antibody (ab136109) at 1/500 dilution

All lanes:

RAW 264.7 cell lysate at 30 µg

Predicted band size: 33 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human HSD17B11 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q8NBQ5

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab136109 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hsd17b11 also known as type 11 17-beta hydroxysteroid dehydrogenase is an enzyme that plays a role in steroid metabolism by catalyzing the conversion of less active 17-keto steroids to more active 17-beta-hydroxy steroids. The dehydrogenase weighs approximately 34 kDa and is found in various tissues but it is highly expressed in the liver and other steroidogenic tissues. As an NAD(P)-dependent oxidoreductase it contributes to maintaining steroid homeostasis within the cellular environment.
Biological function summary

Hsd17b11 influences steroidal balance by regulating the levels of active and inactive steroid hormones. It is sometimes associated with lipid metabolism processes but remains independent not a part of any known enzymatic complex. By controlling hormone levels Hsd17b11 impacts cellular functions related to metabolism growth and reproduction reinforcing its importance in maintaining proper physiological conditions.

Pathways

Hsd17b11 participates in steroid hormone metabolism and has roles within the broader steroidogenic pathway. It is related to the regulation of sex steroids closely working with enzymes like Hsd17b3 and Hsd17b2 which also modulate steroid hormones. These interactions contribute to comprehensive steroid biosynthesis and degradation pathways forming a network critical for endocrine system health.

Several studies have linked Hsd17b11 to disorders of steroid metabolism including polycystic ovary syndrome (PCOS) and some liver dysfunctions. Changes in its activity can affect steroid hormone levels perturbed in PCOS which often associates with aberrant androgen production. In metabolic liver disorders altered Hsd17b11 activity may disrupt lipid metabolism. The enzyme may also interact indirectly with proteins like SHBG (sex hormone-binding globulin) in these contexts influencing disease pathology and presentation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
See full target information HSD17B11
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of natural products 83:3080-3092 PubMed33021790

2020

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Corena V Grant,Shengxin Cai,April L Risinger,Huiyun Liang,Barry R O'Keefe,John G Doench,Robert H Cichewicz,Susan L Mooberry

Molecular cell 77:1251-1264.e9 PubMed32023484

2020

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Niklas Mejhert,Leena Kuruvilla,Katlyn R Gabriel,Shane D Elliott,Marie-Aude Guie,Huajin Wang,Zon Weng Lai,Elizabeth A Lane,Romain Christiano,Nika N Danial,Robert V Farese,Tobias C Walther

Reproduction (Cambridge, England) 157:115-126 PubMed30407918

2018

Identification and characterization of ERV transcripts in goat embryos.

Applications

Unspecified application

Species

Unspecified reactive species

Ruizhi Deng,Chengquan Han,Lu Zhao,Qing Zhang,Beifen Yan,Rui Cheng,Biao Wei,Peng Meng,Tingchao Mao,Yong Zhang,Jun Liu

Biochimica et biophysica acta. Molecular and cell 1863:881-894 PubMed29702244

2018

Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals.

Applications

WB

Species

Unspecified reactive species

Yangli Liu,Shimeng Xu,Congyan Zhang,Xiaotong Zhu,Mirza Ahmed Hammad,Xuelin Zhang,Mark Christian,Hong Zhang,Pingsheng Liu
View all publications
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