AB65156

Anti-HSD3B1 antibody

Name: Anti-HSD3B1 antibody (ab65156) | Abcam
Brand: Abcam Limited
SKU: AB65156
Rating: 5 (3 reviews)

(3 Reviews)

(18 Publications)

Rabbit Polyclonal HSD3B1 antibody. Suitable for ELISA and reacts with Mouse samples. Cited in 18 publications.

View Alternative Names

Hsd3b, Hsd3b1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase, 3-beta-HSD I

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.

See full target information Hsd3b1

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Publications (18)

Recent publications for all applications. Explore the full list and refine your search

Reproductive biology and endocrinology : RB&E 22:82 PubMed39010074

2024

Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhao,Chunbiao Fan,Tongtong Qie,Xinrui Fu,Xiaoshuang Chen,Yujia Wang,Yuan Wu,Xinyao Fu,Kesong Shi,Wenlong Yan,Haiquan Yu

Virologica Sinica 38:66-74 PubMed36241087

2022

Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yang,Chen Zhang,Yan-Hua Wu,Li-Bo Liu,Zi-Da Zhen,Dong-Ying Fan,Zheng-Ran Song,Jia-Tong Chang,Pei-Gang Wang,Jing An

Scientific reports 11:4486 PubMed33627800

2021

The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yayoi Ikeda,Ayako Tagami,Mamiko Maekawa,Akiko Nagai

Drug design, development and therapy 13:2811-2824 PubMed31496657

2019

Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxue Shi,Lijie Fu

Acta histochemica 121:611-618 PubMed31126612

2019

Do estrogens regulate lipid status in testicular steroidogenic Leydig cell?

Applications

Unspecified application

Species

Unspecified reactive species

A Milon,M Kaczmarczyk,P Pawlicki,B Bilinska,M Duliban,E Gorowska-Wojtowicz,W Tworzydlo,M Kotula-Balak

International journal of endocrinology 2019:6785289 PubMed31263496

2019

Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function.

Applications

Unspecified application

Species

Unspecified reactive species

Qingtao Yang,Xuxia Sui,Junjun Cao,Caixia Liu,Shukai Zheng,Mian Bao,Yuanni Huang,Kusheng Wu

European journal of medicinal chemistry 176:21-40 PubMed31091478

2019

Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Bai,Jia Xie,Yajing Xing,Li-Ting Wang,Jiuqing Xie,Fan Yang,Ting Liu,Mingyao Liu,Jie Tang,Zhengfang Yi,Wen-Wei Qiu

RSC advances 9:9709-9717 PubMed35520707

2019

Discovery of methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Bai,Jia Xie,Li-Ting Wang,Yajing Xing,Qian-Ru Jiang,Fan Yang,Jie Tang,Zhengfang Yi,Wen-Wei Qiu

Journal of hazardous materials 358:256-264 PubMed29990813

2018

Subchronic reproductive effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFAES), an alternative to PFOS, on adult male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiujuan Zhou,Jianshe Wang,Nan Sheng,Ruina Cui,Yiqun Deng,Jiayin Dai

Biomaterials 177:125-138 PubMed29886385

2018

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Farina,Corrine Ying Xuan Chua,Andrea Ballerini,Usha Thekkedath,Jenolyn F Alexander,Jessica R Rhudy,Gianluca Torchio,Daniel Fraga,Ravi R Pathak,Mariana Villanueva,Crystal S Shin,Jean A Niles,Raffaella Sesana,Danilo Demarchi,Andrew G Sikora,Ghanashyam S Acharya,A Osama Gaber,Joan E Nichols,Alessandro Grattoni

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HSD3B1 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Product protocols

Target data

Publications (18)

Product promise