AB24503

Anti-Hsp105/HSP110 antibody

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(4 Publications)

Rabbit Polyclonal Hsp105/HSP110 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

HSP105, HSP110, KIAA0201, HSPH1, Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, Heat shock protein family H member 1

1 Images

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Western blot - Anti-Hsp105/HSP110 antibody (AB24503)

All lanes:

Western blot - Anti-Hsp105/HSP110 antibody (ab24503)

All lanes:

HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (<a href='/en-us/products/unavailable/hela-human-epithelial-carcinoma-cell-line-whole-cell-lysate-ab7898'>ab7898</a>)

Predicted band size: 96 kDa

Observed band size: 105 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-4 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3390 Hsp105 Antibody. 3390-100 is the same size as the 100 µg size of ab24503.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hsp105 also known as HSP110 is a member of the heat shock protein family. With a molecular mass of approximately 105 kDa this protein functions as a molecular chaperone. It assists in the proper folding of proteins and prevents aggregation especially under stress conditions. Hsp105 is expressed in various tissues including the brain heart and skeletal muscles indicating its widespread roles in maintaining cellular protein homeostasis.

Biological function summary

Hsp105 plays an essential role in protein folding and stress responses. It forms part of a cellular complex that includes other chaperones like Hsp70 and Hsp40. This interaction is critical in refolding denatured proteins and preventing the accumulation of misfolded proteins. In the cell the chaperone activity of Hsp105 helps in managing protein quality control particularly during heat shock and other stress conditions.

Pathways

This protein integrates within signaling cascades associated with stress responses and apoptosis. It is an important player in the HSF1-mediated heat shock response pathway which regulates the expression of various heat shock proteins. Additionally Hsp105 interacts with proteins like Hsp70 within this pathway coordinating cellular mechanisms that protect against protein-damaging conditions. Another pathway in which Hsp105 is involved might be the ubiquitin-proteasome pathway facilitating the degradation of damaged proteins.

Hsp105 has connections to neurodegenerative disorders and cancer. Studies show that its overexpression may link to tumor resistance against chemotherapy by stabilizing proteins involved in cell survival pathways. In neurodegenerative diseases like Alzheimer's Hsp105 binds to tau proteins potentially impacting their normal function and aggregation. It works alongside related proteins such as Hsp70 in these contexts highlighting its role in the pathogenesis and progression of these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed : 24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

See full target information HSPH1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Genome biology 25:210 PubMed39107855

2024

Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation.

Applications

Unspecified application

Species

Unspecified reactive species

Vincent Jonchère,Hugo Montémont,Enora Le Scanf,Aurélie Siret,Quentin Letourneur,Emmanuel Tubacher,Christophe Battail,Assane Fall,Karim Labreche,Victor Renault,Toky Ratovomanana,Olivier Buhard,Ariane Jolly,Philippe Le Rouzic,Cody Feys,Emmanuelle Despras,Habib Zouali,Rémy Nicolle,Pascale Cervera,Magali Svrcek,Pierre Bourgoin,Hélène Blanché,Anne Boland,Jérémie Lefèvre,Yann Parc,Mehdi Touat,Franck Bielle,Danielle Arzur,Gwennina Cueff,Catherine Le Jossic-Corcos,Gaël Quéré,Gwendal Dujardin,Marc Blondel,Cédric Le Maréchal,Romain Cohen,Thierry André,Florence Coulet,Pierre de la Grange,Aurélien de Reyniès,Jean-François Fléjou,Florence Renaud,Agusti Alentorn,Laurent Corcos,Jean-François Deleuze,Ada Collura,Alex Duval

Cancers 15: PubMed38067355

2023

HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets.

Applications

Unspecified application

Species

Unspecified reactive species

Roberta Gonnella,Roberta Zarrella,Michele Di Crosta,Rossella Benedetti,Andrea Arena,Roberta Santarelli,Maria Saveria Gilardini Montani,Gabriella D'Orazi,Mara Cirone

Cellular and molecular life sciences : CMLS 79:332 PubMed35648235

2022

Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Kathleen Noel,A 'dem Bokhari,Romane Bertrand,Florence Renaud,Pierre Bourgoin,Romain Cohen,Magali Svrcek,Anne-Christine Joly,Alex Duval,Ada Collura

PloS one 6:e26319 PubMed22022600

2011

The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.

Applications

IP, IP

Species

Human, Rat

James Shorter

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Hsp105/HSP110 antibody

Western blot - Anti-Hsp105/HSP110 antibody (AB24503)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

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Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise