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AB210559

Anti-Hsp70l antibody

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(1 Publication)

Rabbit Polyclonal Hsp70l antibody. Suitable for WB and reacts with Zebrafish samples. Cited in 1 publication.
1 Images
Western blot - Anti-Hsp70l antibody (AB210559)
  • WB

Supplier Data

Western blot - Anti-Hsp70l antibody (AB210559)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-Hsp70l antibody (ab210559) at 1/1000 dilution

All lanes:

Zebrafish embryo tissue extracts at 30 µg

Predicted band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Zebrafish

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hsp70l also known as Heat Shock Protein 70-like is a molecular chaperone with an estimated mass of around 70 kDa. It plays a role in protein folding prevention of protein aggregation and assistance in protein transport across cellular membranes. Hsp70l expressions occur mainly in eukaryotic cells especially in response to cellular stress conditions. The presence of Hsp70l in various cellular compartments including the cytoplasm and organelles supports a range of cellular functions to maintain proteostasis.
Biological function summary

The cellular functions and stress response mechanisms insert Hsp70l in various biological processes. It often associates with the Hsp90 complex to assist in the maturation of client proteins. This protein complex facilitates the stabilization and activation of a wide range of substrates including kinases and transcription factors. The participation of Hsp70l in these complexes highlights its role in cellular homeostasis and stress adaptation mechanisms.

Pathways

Hsp70l plays critical roles in cellular stress response and protein repair pathways. An essential pathway includes the unfolded protein response pathway where Hsp70l contributes to refolding damaged proteins or targeting them for degradation. Additionally Hsp70l interacts with proteins like Hip and Hop which modulate its activity within these pathways. Through these interactions Hsp70l supports cellular resilience to environmental and physiological stress.

Hsp70l links significantly to neurodegenerative diseases and certain cancers. In neurodegenerative conditions Hsp70l associates with proteins like tau and alpha-synuclein aiding in their proper folding and reducing their aggregation. In cancer increased Hsp70l levels have associations with enhanced tumor cell survival and resistance to chemotherapy. Modulating Hsp70l activity presents a potential therapeutic target in treating such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Hsp70l
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS chemical neuroscience 12:4491-4499 PubMed34812607

2021

Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.

Applications

Unspecified application

Species

Unspecified reactive species

Yulong Xu,Yiming Xu,Savannah Biby,Ping Bai,Yan Liu,Can Zhang,Changning Wang,Shijun Zhang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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